Αρχή φόρμας

Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors.

Karalis TT, Heldin P, Vynios DH, Neill T, Buraschi S, Iozzo RV, Karamanos NK, Skandalis SS.

Matrix Biol. 2019 May;78-79:118-138. doi: 10.1016/j.matbio.2018.04.007. Epub 2018 Apr 16.

Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration.

Lampropoulou E, Logoviti I, Koutsioumpa M, Hatziapostolou M, Polytarchou C, Skandalis SS, Hellman U, Fousteris M, Nikolaropoulos S, Choleva E, Lamprou M, Skoura A, Megalooikonomou V, Papadimitriou E.

Sci Rep. 2018 Apr 12;8(1):5893. doi: 10.1038/s41598-018-24326-x.

Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production.

Heldin P, Lin CY, Kolliopoulos C, Chen YH, Skandalis SS.

Matrix Biol. 2019 May;78-79:100-117. doi: 10.1016/j.matbio.2018.01.017. Epub 2018 Jan 31. Review.

IGF-IR cooperates with ERα to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM molecules.

Afratis NA, Bouris P, Skandalis SS, Multhaupt HA, Couchman JR, Theocharis AD, Karamanos NK.

Sci Rep. 2017 Jan 12;7:40138. doi: 10.1038/srep40138.

Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer.

Karousou E, Misra S, Ghatak S, Dobra K, Götte M, Vigetti D, Passi A, Karamanos NK, Skandalis SS.

Matrix Biol. 2017 May;59:3-22. doi: 10.1016/j.matbio.2016.10.001. Epub 2016 Oct 13. Review.

Impact of Extracellular Matrix on Cellular Behavior: A Source of Molecular Targets in Disease.

Skandalis SS, Dobra K, Götte M, Karousou E, Misra S.

Biomed Res Int. 2015;2015:482879. doi: 10.1155/2015/482879. Epub 2015 Nov 5. No abstract available.

Extracellular matrix structure.

Theocharis AD, Skandalis SS, Gialeli C, Karamanos NK.

Adv Drug Deliv Rev. 2016 Feb 1;97:4-27. doi: 10.1016/j.addr.2015.11.001. Epub 2015 Nov 10. Review.

Insights into the key roles of proteoglycans in breast cancer biology and translational medicine.

Theocharis AD, Skandalis SS, Neill T, Multhaupt HA, Hubo M, Frey H, Gopal S, Gomes A, Afratis N, Lim HC, Couchman JR, Filmus J, Sanderson RD, Schaefer L, Iozzo RV, Karamanos NK.

Biochim Biophys Acta. 2015 Apr;1855(2):276-300. doi: 10.1016/j.bbcan.2015.03.006. Epub 2015 Mar 28. Review.

Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells.

Bouris P, Skandalis SS, Piperigkou Z, Afratis N, Karamanou K, Aletras AJ, Moustakas A, Theocharis AD, Karamanos NK.

Matrix Biol. 2015 Apr;43:42-60. doi: 10.1016/j.matbio.2015.02.008. Epub 2015 Feb 27.

Cell-matrix interactions: focus on proteoglycan-proteinase interplay and pharmacological targeting in cancer.

Theocharis AD, Gialeli C, Bouris P, Giannopoulou E, Skandalis SS, Aletras AJ, Iozzo RV, Karamanos NK.

FEBS J. 2014 Nov;281(22):5023-42. doi: 10.1111/febs.12927. Epub 2014 Nov 6. Review.

Advances and advantages of nanomedicine in the pharmacological targeting of hyaluronan-CD44 interactions and signaling in cancer.

Skandalis SS, Gialeli C, Theocharis AD, Karamanos NK.

Adv Cancer Res. 2014;123:277-317. doi: 10.1016/B978-0-12-800092-2.00011-3. Review.

Serglycin: at the crossroad of inflammation and malignancy.

Korpetinou A, Skandalis SS, Labropoulou VT, Smirlaki G, Noulas A, Karamanos NK, Theocharis AD.

Front Oncol. 2014 Jan 13;3:327. doi: 10.3389/fonc.2013.00327. eCollection 2014 Jan 13. Review.

Serglycin is implicated in the promotion of aggressive phenotype of breast cancer cells.

Korpetinou A, Skandalis SS, Moustakas A, Happonen KE, Tveit H, Prydz K, Labropoulou VT, Giannopoulou E, Kalofonos HP, Blom AM, Karamanos NK, Theocharis AD.

PLoS One. 2013 Oct 31;8(10):e78157. doi: 10.1371/journal.pone.0078157. eCollection 2013.

Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: focus on the role and impact of proteoglycans.

Skandalis SS, Afratis N, Smirlaki G, Nikitovic D, Theocharis AD, Tzanakakis GN, Karamanos NK.

Matrix Biol. 2014 Apr;35:182-93. doi: 10.1016/j.matbio.2013.09.002. Epub 2013 Sep 21. Review.

Extracellular matrix degradation and tissue remodeling in periprosthetic loosening and osteolysis: focus on matrix metalloproteinases, their endogenous tissue inhibitors, and the proteasome.

Syggelos SA, Aletras AJ, Smirlaki I, Skandalis SS.

Biomed Res Int. 2013;2013:230805. doi: 10.1155/2013/230805. Epub 2013 Jun 19. Review.

Expression of syndecan-4 and correlation with metastatic potential in testicular germ cell tumours.

Labropoulou VT, Skandalis SS, Ravazoula P, Perimenis P, Karamanos NK, Kalofonos HP, Theocharis AD.

Biomed Res Int. 2013;2013:214864. doi: 10.1155/2013/214864. Epub 2013 Jun 15.

Evaluation of the coordinated actions of estrogen receptors with epidermal growth factor receptor and insulin-like growth factor receptor in the expression of cell surface heparan sulfate proteoglycans and cell motility in breast cancer cells.

Tsonis AI, Afratis N, Gialeli C, Ellina MI, Piperigkou Z, Skandalis SS, Theocharis AD, Tzanakakis GN, Karamanos NK.

FEBS J. 2013 May;280(10):2248-59. doi: 10.1111/febs.12162. Epub 2013 Feb 27.

Interplay between αvβ3 integrin and nucleolin regulates human endothelial and glioma cell migration.

Koutsioumpa M, Polytarchou C, Courty J, Zhang Y, Kieffer N, Mikelis C, Skandalis SS, Hellman U, Iliopoulos D, Papadimitriou E.

J Biol Chem. 2013 Jan 4;288(1):343-54. doi: 10.1074/jbc.M112.387076. Epub 2012 Nov 16.

Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma.

Filou S, Stylianou M, Triantaphyllidou IE, Papadas T, Mastronikolis NS, Goumas PD, Papachristou DJ, Ravazoula P, Skandalis SS, Vynios DH.

Biochimie. 2013 Apr;95(4):725-34. doi: 10.1016/j.biochi.2012.10.022. Epub 2012 Nov 3.

Targeting the tumor proteasome as a mechanism to control the synthesis and bioactivity of matrix macromolecules.

Skandalis SS, Aletras AJ, Gialeli C, Theocharis AD, Afratis N, Tzanakakis GN, Karamanos NK.

Curr Mol Med. 2012 Sep;12(8):1068-82. Review.

IQGAP1 regulates hyaluronan-mediated fibroblast motility and proliferation.

Kozlova I, Ruusala A, Voytyuk O, Skandalis SS, Heldin P.

Cell Signal. 2012 Sep;24(9):1856-62. doi: 10.1016/j.cellsig.2012.05.013. Epub 2012 May 22.

Versican but not decorin accumulation is related to malignancy in mammographically detected high density and malignant-appearing microcalcifications in non-palpable breast carcinomas.

Skandalis SS, Labropoulou VT, Ravazoula P, Likaki-Karatza E, Dobra K, Kalofonos HP, Karamanos NK, Theocharis AD.

BMC Cancer. 2011 Jul 26;11:314. doi: 10.1186/1471-2407-11-314.

Pathophysiology and pharmacological targeting of tumor-induced bone disease: current status and emerging therapeutic interventions.

Labropoulou VT, Theocharis AD, Symeonidis A, Skandalis SS, Karamanos NK, Kalofonos HP.

Curr Med Chem. 2011;18(11):1584-98. Review.

Hyaluronan-CD44 interactions as potential targets for cancer therapy.

Misra S, Heldin P, Hascall VC, Karamanos NK, Skandalis SS, Markwald RR, Ghatak S.

FEBS J. 2011 May;278(9):1429-43. doi: 10.1111/j.1742-4658.2011.08071.x. Epub 2011 Mar 25. Review.

Proteomic identification of CD44 interacting proteins.

Skandalis SS, Kozlova I, Engström U, Hellman U, Heldin P.

IUBMB Life. 2010 Nov;62(11):833-40. doi: 10.1002/iub.392.

Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting.

Theocharis AD, Skandalis SS, Tzanakakis GN, Karamanos NK.

FEBS J. 2010 Oct;277(19):3904-23. doi: 10.1111/j.1742-4658.2010.07800.x. Epub 2010 Aug 31. Review.

The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination.

Karousou E, Kamiryo M, Skandalis SS, Ruusala A, Asteriou T, Passi A, Yamashita H, Hellman U, Heldin CH, Heldin P.

J Biol Chem. 2010 Jul 30;285(31):23647-54. doi: 10.1074/jbc.M110.127050. Epub 2010 May 27.

Keratan sulfate-containing proteoglycans in sheep brain with particular reference to phosphacan and synaptic vesicle proteoglycan isoforms.

Sinouris EA, Skandalis SS, Kilia V, Theocharis AD, Theocharis DA, Ravazoula P, Vynios DH, Papageorgakopoulou N.

Biomed Chromatogr. 2009 May;23(5):455-63. doi: 10.1002/bmc.1127.

Biochemical changes of extracellular proteoglycans in squamous cell laryngeal carcinoma.

Vynios DH, Theocharis DA, Papageorgakopoulou N, Papadas TA, Mastronikolis NS, Goumas PD, Stylianou M, Skandalis SS.

Connect Tissue Res. 2008;49(3):239-43. doi: 10.1080/03008200802147662. Review.

Importance of hyaluronan-CD44 interactions in inflammation and tumorigenesis.

Heldin P, Karousou E, Bernert B, Porsch H, Nishitsuka K, Skandalis SS.

Connect Tissue Res. 2008;49(3):215-8. doi: 10.1080/03008200802143323. Review.

Hyaluronan and chondroitin sulfate proteoglycans in the supramolecular organization of the mammalian vitreous body.

Theocharis DA, Skandalis SS, Noulas AV, Papageorgakopoulou N, Theocharis AD, Karamanos NK.

Connect Tissue Res. 2008;49(3):124-8. doi: 10.1080/03008200802148496. Review.

Glycosaminoglycan in cerebrum, cerebellum and brainstem of young sheep brain with particular reference to compositional and structural variations of chondroitin-dermatan sulfate and hyaluronan.

Kilia V, Skandalis SS, Theocharis AD, Theocharis DA, Karamanos NK, Papageorgakopoulou N.

Biomed Chromatogr. 2008 Sep;22(9):931-8. doi: 10.1002/bmc.1010.

Stage-related decorin and versican expression in human laryngeal cancer.

Stylianou M, Skandalis SS, Papadas TA, Mastronikolis NS, Theocharis DA, Papageorgakopoulou N, Vynios DH.

Anticancer Res. 2008 Jan-Feb;28(1A):245-51.

The structural and compositional changes of glycosaminoglycans are closely associated with tissue type in human laryngeal cancer.

Skandalis SS, Stylianou M, Vynios DH, Papageorgakopoulou N, Theocharis DA.

Biochimie. 2007 Dec;89(12):1573-80. Epub 2007 Jul 17.

Chondroitin sulphate proteoglycans in the vitreous gel of sheep and goat.

Skandalis SS, Theocharis DA, Noulas AV.

Biomed Chromatogr. 2007 May;21(5):451-7.

The greatly increased amounts of accumulated versican and decorin with specific post-translational modifications may be closely associated with the malignant phenotype of pancreatic cancer.

Skandalis SS, Kletsas D, Kyriakopoulou D, Stavropoulos M, Theocharis DA.

Biochim Biophys Acta. 2006 Aug;1760(8):1217-25. Epub 2006 Apr 7.

The increased accumulation of structurally modified versican and decorin is related with the progression of laryngeal cancer.

Skandalis SS, Theocharis AD, Papageorgakopoulou N, Vynios DH, Theocharis DA.

Biochimie. 2006 Sep;88(9):1135-43. Epub 2006 Apr 25.

Cartilage aggrecan undergoes significant compositional and structural alterations during laryngeal cancer.

Skandalis SS, Theocharis AD, Vynios DH, Papageorgakopoulou N, Hjerpe A, Karamanos NK, Theocharis DA.

Biochim Biophys Acta. 2006 Jul;1760(7):1046-53. Epub 2006 Mar 9.

The extractability of extracellular matrix components as a marker of cartilage remodeling in laryngeal squamous cell carcinoma.

Skandalis SS, Theocharis DA, Papageorgakopoulou N, Vynios DH.

Biochim Biophys Acta. 2005 Jan 18;1721(1-3):81-8. Epub 2004 Nov 1.

Variations in content and structure of glycosaminoglycans of the vitreous gel from different mammalian species.

Noulas AV, Skandalis SS, Feretis E, Theocharis DA, Karamanos NK.

Biomed Chromatogr. 2004 Sep;18(7):457-61.

Matrix proteoglycans are markedly affected in advanced laryngeal squamous cell carcinoma.

Skandalis SS, Theocharis AD, Theocharis DA, Papadas T, Vynios DH, Papageorgakopoulou N.

Biochim Biophys Acta. 2004 Jun 28;1689(2):152-61.

Proteoglycans in human laryngeal cartilage. Identification of proteoglycan types in successive cartilage extracts with particular reference to aggregating proteoglycans.

Skandalis SS, Theocharis AD, Vynios DH, Theocharis DA, Papageorgakopoulou N.

Biochimie. 2004 Mar;86(3):221-9.

Glycosaminoglycans in early chick embryo.

Skandalis SS, Theocharis AD, Papageorgakopoulou N, Zagris N.

Int J Dev Biol. 2003 May;47(4):311-4.

Immunological studies of sheep brain keratan sulphate proteoglycans.

Papageorgakopoulou N, Theocharis AD, Skandalis SS, Vynios DH, Theocharis DA, Tsiganos CP.

Biochimie. 2002 Dec;84(12):1225-8.

Altered content composition and structure of glycosaminoglycans and proteoglycans in gastric carcinoma.

Theocharis AD, Vynios DH, Papageorgakopoulou N, Skandalis SS, Theocharis DA.

Int J Biochem Cell Biol. 2003 Mar;35(3):376-90.

Keratan sulphate in cerebrum, cerebellum and brainstem of sheep brain.

Papageorgakopoulou N, Theocharis AD, Skandalis SS, Vynios DH, Theocharis DA, Tsiganos CP.

Biochimie. 2001 Oct;83(10):973-8.