Αρχή φόρμας

A guide to hyaluronan and related enzymes in breast cancer: biological significance and diagnostic value.

Velesiotis C, Vasileiou S, Vynios DH.

FEBS J. 2019 Apr 24. doi: 10.1111/febs.14860. [Epub ahead of print] Review.

Analyzing Hyaluronidases in Biological Fluids.

Velesiotis C, Vasileiou S, Vynios DH.

Methods Mol Biol. 2019;1952:127-142. doi: 10.1007/978-1-4939-9133-4_12.

Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors.

Karalis TT, Heldin P, Vynios DH, Neill T, Buraschi S, Iozzo RV, Karamanos NK, Skandalis SS.

Matrix Biol. 2019 May;78-79:118-138. doi: 10.1016/j.matbio.2018.04.007. Epub 2018 Apr 16.

Lumican effectively regulates the estrogen receptors-associated functional properties of breast cancer cells, expression of matrix effectors and epithelial-to-mesenchymal transition.

Karamanou K, Franchi M, Piperigkou Z, Perreau C, Maquart FX, Vynios DH, Brézillon S.

Sci Rep. 2017 Mar 23;7:45138. doi: 10.1038/srep45138.

The role of heparins and nano-heparins as therapeutic tool in breast cancer.

Afratis NA, Karamanou K, Piperigkou Z, Vynios DH, Theocharis AD.

Glycoconj J. 2017 Jun;34(3):299-307. doi: 10.1007/s10719-016-9742-7. Epub 2016 Oct 24. Review.

Emerging aspects of nanotoxicology in health and disease: From agriculture and food sector to cancer therapeutics.

Piperigkou Z, Karamanou K, Engin AB, Gialeli C, Docea AO, Vynios DH, Pavão MS, Golokhvast KS, Shtilman MI, Argiris A, Shishatskaya E, Tsatsakis AM.

Food Chem Toxicol. 2016 May;91:42-57. doi: 10.1016/j.fct.2016.03.003. Epub 2016 Mar 8. Review.

Hyaluronan synthases and hyaluronidases in nasal polyps.

Panogeorgou T, Tserbini E, Filou S, Vynios DH, Naxakis SS, Papadas TA, Goumas PD, Mastronikolis NS.

Eur Arch Otorhinolaryngol. 2016 Jul;273(7):1801-8. doi: 10.1007/s00405-015-3848-6. Epub 2015 Dec 10.

Biochemical and toxicological evaluation of nano-heparins in cell functional properties, proteasome activation and expression of key matrix molecules.

Piperigkou Z, Karamanou K, Afratis NA, Bouris P, Gialeli C, Belmiro CL, Pavão MS, Vynios DH, Tsatsakis AM.

Toxicol Lett. 2016 Jan 5;240(1):32-42. doi: 10.1016/j.toxlet.2015.10.005. Epub 2015 Oct 22.

ADAMTS expression in colorectal cancer.

Filou S, Korpetinou A, Kyriakopoulou D, Bounias D, Stavropoulos M, Ravazoula P, Papachristou DJ, Theocharis AD, Vynios DH.

PLoS One. 2015 Mar 18;10(3):e0121209. doi: 10.1371/journal.pone.0121209. eCollection 2015.

Metabolism of cartilage proteoglycans in health and disease.

Vynios DH.

Biomed Res Int. 2014;2014:452315. doi: 10.1155/2014/452315. Epub 2014 Jul 3. Review.

Syndecans as modulators and potential pharmacological targets in cancer progression.

Barbouri D, Afratis N, Gialeli C, Vynios DH, Theocharis AD, Karamanos NK.

Front Oncol. 2014 Feb 3;4:4. doi: 10.3389/fonc.2014.00004. eCollection 2014. Review.

Pre-treatment gelatinases' serum levels and post-treatment changes in laryngeal cancer patients.

Tsiropoulos G, Papadas T, Triantaphyllidou Ie, Naxakis S, Markou K, Triaridis S, Vital I, Goumas P, Vynios D.

Hippokratia. 2013 Jul;17(3):220-7.

Hyaluronidases and their inhibitors in the serum of colorectal carcinoma patients.

Kolliopoulos C, Bounias D, Bouga H, Kyriakopoulou D, Stavropoulos M, Vynios DH.

J Pharm Biomed Anal. 2013 Sep;83:299-304. doi: 10.1016/j.jpba.2013.05.037. Epub 2013 May 28.

Presence of hyaluronidase isoforms in nasal polyps.

Hatziri A, Vynios DH, Panogeorgou T, Bouga H, Triantaphyllidou IE, Naxakis SS, Stathas T, Aletras AJ, Kourousis C, Mastronikolis NS.

Eur Rev Med Pharmacol Sci. 2013 Jan;17(2):247-52.

Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma.

Filou S, Stylianou M, Triantaphyllidou IE, Papadas T, Mastronikolis NS, Goumas PD, Papachristou DJ, Ravazoula P, Skandalis SS, Vynios DH.

Biochimie. 2013 Apr;95(4):725-34. doi: 10.1016/j.biochi.2012.10.022. Epub 2012 Nov 3.

Biomechanical and structural changes following the decellularization of bovine pericardial tissues for use as a tissue engineering scaffold.

Pagoulatou E, Triantaphyllidou IE, Vynios DH, Papachristou DJ, Koletsis E, Deligianni D, Mavrilas D.

J Mater Sci Mater Med. 2012 Jun;23(6):1387-96. doi: 10.1007/s10856-012-4620-8. Epub 2012 Mar 28.

Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer.

Kalathas D, Theocharis DA, Bounias D, Kyriakopoulou D, Papageorgakopoulou N, Stavropoulos MS, Vynios DH.

Mol Med Rep. 2011 Mar-Apr;4(2):363-8. doi: 10.3892/mmr.2011.431. Epub 2011 Jan 25.

The chondroitin/dermatan sulfate synthesizing and modifying enzymes in laryngeal cancer: expressional and epigenetic studies.

Kalathas D, Triantaphyllidou IE, Mastronikolis NS, Goumas PD, Papadas TA, Tsiropoulos G, Vynios DH.

Head Neck Oncol. 2010 Oct 7;2:27. doi: 10.1186/1758-3284-2-27.

Involvement of hyaluronidases in colorectal cancer.

Bouga H, Tsouros I, Bounias D, Kyriakopoulou D, Stavropoulos MS, Papageorgakopoulou N, Theocharis DA, Vynios DH.

BMC Cancer. 2010 Sep 17;10:499. doi: 10.1186/1471-2407-10-499.

Alterations of glycosaminoglycan disaccharide content and composition in colorectal cancer: structural and expressional studies.

Kalathas D, Theocharis DA, Bounias D, Kyriakopoulou D, Papageorgakopoulou N, Stavropoulos MS, Vynios DH.

Oncol Rep. 2009 Aug;22(2):369-75.

Keratan sulfate-containing proteoglycans in sheep brain with particular reference to phosphacan and synaptic vesicle proteoglycan isoforms.

Sinouris EA, Skandalis SS, Kilia V, Theocharis AD, Theocharis DA, Ravazoula P, Vynios DH, Papageorgakopoulou N.

Biomed Chromatogr. 2009 May;23(5):455-63. doi: 10.1002/bmc.1127.

Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP(87-99)) epitope elicits a Th1 polarized response by T cells isolated from multiple sclerosis patients: implications in triggering disease.

Deraos G, Chatzantoni K, Matsoukas MT, Tselios T, Deraos S, Katsara M, Papathanasopoulos P, Vynios D, Apostolopoulos V, Mouzaki A, Matsoukas J.

J Med Chem. 2008 Dec 25;51(24):7834-42. doi: 10.1021/jm800891n.

Biochemical changes of extracellular proteoglycans in squamous cell laryngeal carcinoma.

Vynios DH, Theocharis DA, Papageorgakopoulou N, Papadas TA, Mastronikolis NS, Goumas PD, Stylianou M, Skandalis SS.

Connect Tissue Res. 2008;49(3):239-43. doi: 10.1080/03008200802147662. Review.

Stage-related decorin and versican expression in human laryngeal cancer.

Stylianou M, Skandalis SS, Papadas TA, Mastronikolis NS, Theocharis DA, Papageorgakopoulou N, Vynios DH.

Anticancer Res. 2008 Jan-Feb;28(1A):245-51.

Expression of metalloproteinases and their tissue inhibitors in squamous cell laryngeal carcinoma.

Christopoulos TA, Papageorgakopoulou N, Ravazoula P, Mastronikolis NS, Papadas TA, Theocharis DA, Vynios DH.

Oncol Rep. 2007 Oct;18(4):855-60.

The structural and compositional changes of glycosaminoglycans are closely associated with tissue type in human laryngeal cancer.

Skandalis SS, Stylianou M, Vynios DH, Papageorgakopoulou N, Theocharis DA.

Biochimie. 2007 Dec;89(12):1573-80. Epub 2007 Jul 17.

Advances in the analysis of chondroitin/dermatan sulfate.

Stylianou M, Triantaphyllidou IE, Vynios DH.

Adv Pharmacol. 2006;53:141-66. Review. No abstract available.

Detection, quantification, and glycotyping of prion protein in specifically activated enzyme-linked immunosorbent assay plates.

Triantaphyllidou IE, Sklaviadis T, Vynios DH.

Anal Biochem. 2006 Dec 15;359(2):176-82. Epub 2006 Oct 25.

Hyaluronidase and CD44 hyaluronan receptor expression in squamous cell laryngeal carcinoma.

Christopoulos TA, Papageorgakopoulou N, Theocharis DA, Mastronikolis NS, Papadas TA, Vynios DH.

Biochim Biophys Acta. 2006 Jul;1760(7):1039-45. Epub 2006 Apr 4.

The increased accumulation of structurally modified versican and decorin is related with the progression of laryngeal cancer.

Skandalis SS, Theocharis AD, Papageorgakopoulou N, Vynios DH, Theocharis DA.

Biochimie. 2006 Sep;88(9):1135-43. Epub 2006 Apr 25.

Cartilage aggrecan undergoes significant compositional and structural alterations during laryngeal cancer.

Skandalis SS, Theocharis AD, Vynios DH, Papageorgakopoulou N, Hjerpe A, Karamanos NK, Theocharis DA.

Biochim Biophys Acta. 2006 Jul;1760(7):1046-53. Epub 2006 Mar 9.

Preparation of cross-linked cellulases and their application for the enzymatic production of glucose from municipal paper wastes.

Filos G, Tziala T, Lagios G, Vynios DH.

Prep Biochem Biotechnol. 2006;36(2):111-25.

Autoantibodies against aggrecan in systemic rheumatic diseases.

Vynios DH, Tsagaraki I, Grigoreas GH, Samiotaki M, Panayotou G, Kyriakopoulou D, Georgiou P, Korbakis D, Panayotou A, Nanouri K, Assouti M, Andonopoulos AP.

Biochimie. 2006 Jul;88(7):767-73. Epub 2006 Jan 30.

Selective inhibition of matrix metalloproteinase 2 (gelatinase A) by barium chloride.

Ziouti N, Mastronikolis NS, Andonopoulos AP, Georgakopoulos CD, Vynios DH.

Anal Biochem. 2006 Mar 1;350(1):159-61. Epub 2005 Dec 27. No abstract available.

Collagen type IX and HNK-1 epitope in tears of patients with pseudoexfoliation syndrome.

Assouti M, Vynios DH, Anagnostides ST, Papadopoulos G, Georgakopoulos CD, Gartaganis SP.

Biochim Biophys Acta. 2006 Jan;1762(1):54-8. Epub 2005 Oct 11.

Dynamic mechanical characteristics of intact and structurally modified bovine pericardial tissues.

Mavrilas D, Sinouris EA, Vynios DH, Papageorgakopoulou N.

J Biomech. 2005 Apr;38(4):761-8.

The extractability of extracellular matrix components as a marker of cartilage remodeling in laryngeal squamous cell carcinoma.

Skandalis SS, Theocharis DA, Papageorgakopoulou N, Vynios DH.

Biochim Biophys Acta. 2005 Jan 18;1721(1-3):81-8. Epub 2004 Nov 1.

The presence of a novel extracellular hyaluronidase in squid cranial cartilage.

Tsilemou A, Assouti M, Papageorgakopoulou N, Karamanos NK, Tsiganos CP, Vynios DH.

Biochimie. 2004 Aug;86(8):579-86.

Changes of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in the serum of patients with autoimmune diseases: association with age and disease activity.

Ziouti N, Vynios DH, Aletras AJ, Kyriakopoulou D, Mastorakou A, Andonopoulos A.

Clin Chem Lab Med. 2004;42(8):880-8.

HPLC identification of oversulphated chondroitin as the major glycosaminoglycan of human tonsils.

Triantaphyllidou IE, Mastronikolis NS, Papadas TA, Vynios DH.

Biomed Chromatogr. 2004 Nov;18(9):694-9.

Diagnostic and classification value of metalloproteinases in squamous human laryngeal carcinoma.

Christopoulos TA, Papageorgakopoulou N, Theocharis DA, Aletras AJ, Tsiganos CP, Papadas TA, Mastronikolis NS, Goumas P, Vynios DH.

Int J Oncol. 2004 Aug;25(2):481-5.

Matrix proteoglycans are markedly affected in advanced laryngeal squamous cell carcinoma.

Skandalis SS, Theocharis AD, Theocharis DA, Papadas T, Vynios DH, Papageorgakopoulou N.

Biochim Biophys Acta. 2004 Jun 28;1689(2):152-61.

Proteoglycans in human laryngeal cartilage. Identification of proteoglycan types in successive cartilage extracts with particular reference to aggregating proteoglycans.

Skandalis SS, Theocharis AD, Vynios DH, Theocharis DA, Papageorgakopoulou N.

Biochimie. 2004 Mar;86(3):221-9.

Solid phase assays in glycoconjugate research: applications to the analysis of proteoglycans, glycosaminoglycans and metalloproteinases.

Ziouti N, Triantaphyllidou IE, Assouti M, Papageorgakopoulou N, Kyriakopoulou D, Anagnostides ST, Vynios DH.

J Pharm Biomed Anal. 2004 Mar 1;34(4):771-89. Review.

Changes in HNK-1 epitope and collagen type IX in the aqueous humour of patients with pseudoexfoliation syndrome.

Gartaganis SP, Georgakopoulos CD, Assouti M, Mela EK, Exarchou A, Giannelou I, Gotsis SS, Ziouti N, Vynios DH, Tripathi BJ, Tripathi RC.

Curr Eye Res. 2004 Jan;28(1):5-10.

A solid-phase assay for the quantitative analysis of hyaluronic acid at the nanogram level.

Grigoreas GH, Anagnostides ST, Vynios DH.

Anal Biochem. 2003 Sep 15;320(2):179-84.

Immunological studies of sheep brain keratan sulphate proteoglycans.

Papageorgakopoulou N, Theocharis AD, Skandalis SS, Vynios DH, Theocharis DA, Tsiganos CP.

Biochimie. 2002 Dec;84(12):1225-8.

Altered content composition and structure of glycosaminoglycans and proteoglycans in gastric carcinoma.

Theocharis AD, Vynios DH, Papageorgakopoulou N, Skandalis SS, Theocharis DA.

Int J Biochem Cell Biol. 2003 Mar;35(3):376-90.

Advances in analysis of glycosaminoglycans: its application for the assessment of physiological and pathological states of connective tissues.

Vynios DH, Karamanos NK, Tsiganos CP.

J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Dec 5;781(1-2):21-38. Review.

Ageing research in Greece.

Gonos ES, Agrafiotis D, Dontas AS, Efthimiopoulos S, Galaris D, Karamanos NK, Kletsas D, Kolettas E, Panayotou G, Pratsinis H, Sekeri-Pataryas KE, Simoes D, Sourlingas TG, Stathakos D, Stratigos AJ, Tavernarakis N, Trougakos IP, Tsiganos CP, Vynios DH.

Exp Gerontol. 2002 Jun;37(6):735-47.

Matrix metalloproteinases and their inhibitors in exfoliation syndrome.

Gartaganis SP, Georgakopoulos CD, Mela EK, Exarchou A, Ziouti N, Assouti M, Vynios DH.

Ophthalmic Res. 2002 May-Jun;34(3):165-71.

Alterations in the content and composition of glycosaminoglycans in human laryngeal carcinoma.

Papadas TA, Stylianou M, Mastronikolis NS, Papageorgakopoulou N, Skandalis S, Goumas P, Theocharis DA, Vynios DH.

Acta Otolaryngol. 2002 Apr;122(3):330-7.

A solid phase assay for the determination of heparan sulfate and its application to normal and cancerous human cartilage samples.

Vynios DH, Papadas ThA, Faraos A, Mastronikolis NS, Goumas P, Tsiganos CP.

J Immunoassay Immunochem. 2001;22(4):337-51.

Keratan sulphate in cerebrum, cerebellum and brainstem of sheep brain.

Papageorgakopoulou N, Theocharis AD, Skandalis SS, Vynios DH, Theocharis DA, Tsiganos CP.

Biochimie. 2001 Oct;83(10):973-8.

The interactions of cartilage proteoglycans with collagens are determined by their structures.

Vynios DH, Papageorgakopoulou N, Sazakli H, Tsiganos CP.

Biochimie. 2001 Sep;83(9):899-906.

Characterization of glycosaminoglycans from human normal and scoliotic nasal cartilage with particular reference to dermatan sulfate.

Theocharis AD, Tsara ME, Papageorgakopoulou N, Vynios DH, Theocharis DA.

Biochim Biophys Acta. 2001 Oct 3;1528(2-3):81-8.

Determination and structural characterisation of dermatan sulfate in the presence of other galactosaminoglycans.

Theocharis DA, Papageorgacopoulou N, Vynios DH, Anagnostides ST, Tsiganos CP.

J Chromatogr B Biomed Sci Appl. 2001 Apr 25;754(2):297-309.

Polydispersity and heterogeneity of squid cranial cartilage proteoglycans as assessed by immunochemical methods and electron microscopy.

Vynios DH, Mörgelin M, Papageorgakopoulou N, Tsilemou A, Spyracopoulou G, Zafira M, Tsiganos CP.

Biochimie. 2000 Aug;82(8):773-82.

Changes in protein composition and hydrolytic enzyme activity of Escherichia coli and Hafnia alvei grown in human fluids.

Papageorgakopoulou N, Vynios DH, Adamopoulos P, Stravropoulou C, Papapetropoulou M.

Microbiol Res. 2000 Mar;154(4):363-8.

A solid-phase assay for quantitative analysis of sulfated glycosaminoglycans at the nanogram level. Application to tissue samples.

Vynios DH, Faraos A, Spyracopoulou G, Aletras AJ, Tsiganos CP.

J Pharm Biomed Anal. 1999 Dec;21(4):859-65.

Identification of a protein in squid cranial cartilage with link protein properties.

Tsilemou A, Giannicopoulou P, Vynios DH.

Biochimie. 1998 Jul;80(7):591-4.

Aggrecan immobilization onto polystyrene plates through electrostatic interactions with spermine.

Vynios DH, Vamvacas SS, Kalpaxis DL, Tsiganos CP.

Anal Biochem. 1998 Jun 15;260(1):64-70.

The effect of acylated polyamine derivatives on polyamine uptake mechanism, cell growth, and polyamine pools in Escherichia coli, and the pursuit of structure/activity relationships.

Karahalios P, Mamos P, Vynios DH, Papaioannou D, Kalpaxis DL.

Eur J Biochem. 1998 Feb 1;251(3):998-1004.

Electrophoretic analysis of hydrolytic enzymes of Escherichia coli cells starved in seawater and drinking water: comparison of gelatinolytic, caseinolytic, phosphohydrolytic and hyaluronolytic activities.

Papageorgakopoulou N, Vynios DH, Karayanni K, Maras A, Papapetropoulou M.

Microbiol Res. 1997 Sep;152(3):299-305.

Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage.

Dudhia J, Davidson CM, Wells TM, Vynios DH, Hardingham TE, Bayliss MT.

Biochem J. 1996 Feb 1;313 ( Pt 3):933-40.

Effect of proteoglycans on hydroxyapatite growth in vitro: the role of hyaluronan.

Paschalakis P, Vynios DH, Tsiganos CP, Dalas E, Maniatis C, Koutsoukos PG.

Biochim Biophys Acta. 1993 Oct 3;1158(2):129-36.

Self-aggregation of squid cranial cartilage proteoglycans.

Vynios DH, Mörgelin M, Tsiganos CP.

Matrix. 1992 Dec;12(6):417-26.

Solid-phase synthesis and spectroscopic studies of TRH analogues incorporating cis- and trans-4-hydroxy-L-proline.

Stavropoulos G, Karagiannis K, Vynios D, Papaloannou D, Aksnes DW, Age Frøystein N, Francis GW.

Acta Chem Scand. 1991 Nov;45(10):1047-54.

Squid proteoglycans: isolation and characterization of three populations from cranial cartilage.

Vynios DH, Tsiganos CP.

Biochim Biophys Acta. 1990 Feb 26;1033(2):139-47.

Extraction and fractionation of proteoglycans from squid skin.

Karamanos NK, Aletras AJ, Antonopoulos CA, Tsegenidis T, Tsiganos CP, Vynios DH.

Biochim Biophys Acta. 1988 Jul 14;966(1):36-43.

Rooster comb hyaluronate-protein, a non-covalently linked complex.

Tsiganos CP, Vynios DH, Kalpaxis DL.

Biochem J. 1986 Apr 1;235(1):117-23.

Immobilization of hyaluronate on cellulose fibres and its use for the isolation of cartilage components.

Kalpaxis DL, Vynios DH, Tsiganos CP.

Int J Biochem. 1985;17(1):61-6.

Analysis of the acid polysaccharides from squid cranial cartilage and examination of a novel polysaccharide.

Hjerpe A, Engfeldt B, Tsegenidis T, Antonopoulos CA, Vynios DH, Tsiganos CP.

Biochim Biophys Acta. 1983 May 4;757(1):85-91.