Αρχή φόρμας

Expression and Localization of Glycosaminoglycans/Proteoglycan in Pterygium: An Immunohistochemical Study.

Georgakopoulos CD, Makri OE, Pagoulatos D, Karamanos NK.

Med Hypothesis Discov Innov Ophthalmol. 2019 Spring;8(1):39-43.

The extracellular matrix as a multitasking player in disease.

Theocharis AD, Manou D, Karamanos NK.

FEBS J. 2019 Mar 25. doi: 10.1111/febs.14818. [Epub ahead of print] Review.

The Complex Interplay Between Extracellular Matrix and Cells in Tissues.

Manou D, Caon I, Bouris P, Triantaphyllidou IE, Giaroni C, Passi A, Karamanos NK, Vigetti D, Theocharis AD.

Methods Mol Biol. 2019;1952:1-20. doi: 10.1007/978-1-4939-9133-4_1.

Hyaluronan: molecular size-dependent signaling and biological functions in inflammation and cancer.

Tavianatou AG, Caon I, Franchi M, Piperigkou Z, Galesso D, Karamanos NK.

FEBS J. 2019 Feb 6. doi: 10.1111/febs.14777. [Epub ahead of print] Review.

Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics.

Karamanos NK, Piperigkou Z, Theocharis AD, Watanabe H, Franchi M, Baud S, Brézillon S, Götte M, Passi A, Vigetti D, Ricard-Blum S, Sanderson RD, Neill T, Iozzo RV.

Chem Rev. 2018 Sep 26;118(18):9152-9232. doi: 10.1021/acs.chemrev.8b00354. Epub 2018 Sep 11.

Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases.

Karamanos NK, Theocharis AD, Neill T, Iozzo RV.

Matrix Biol. 2019 Jan;75-76:1-11. doi: 10.1016/j.matbio.2018.08.007. Epub 2018 Aug 18. Review.

Advances in targeting epidermal growth factor receptor signaling pathway in mammary cancer.

Kyriakopoulou K, Kefali E, Piperigkou Z, Bassiony H, Karamanos NK.

Cell Signal. 2018 Nov;51:99-109. doi: 10.1016/j.cellsig.2018.07.010. Epub 2018 Jul 31. Review.

Serglycin promotes breast cancer cell aggressiveness: Induction of epithelial to mesenchymal transition, proteolytic activity and IL-8 signaling.

Bouris P, Manou D, Sopaki-Valalaki A, Kolokotroni A, Moustakas A, Kapoor A, Iozzo RV, Karamanos NK, Theocharis AD.

Matrix Biol. 2018 Dec;74:35-51. doi: 10.1016/j.matbio.2018.05.011. Epub 2018 May 26.

Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors.

Karalis TT, Heldin P, Vynios DH, Neill T, Buraschi S, Iozzo RV, Karamanos NK, Skandalis SS.

Matrix Biol. 2019 May;78-79:118-138. doi: 10.1016/j.matbio.2018.04.007. Epub 2018 Apr 16.

The apparent competitive action of ECM proteases and cross-linking enzymes during fibrosis: Applications to drug discovery.

Afratis NA, Klepfish M, Karamanos NK, Sagi I.

Adv Drug Deliv Rev. 2018 Apr;129:4-15. doi: 10.1016/j.addr.2018.03.004. Epub 2018 Apr 5. Review.

Proteoglycans remodeling in cancer: Underlying molecular mechanisms.

Theocharis AD, Karamanos NK.

Matrix Biol. 2019 Jan;75-76:220-259. doi: 10.1016/j.matbio.2017.10.008. Epub 2017 Nov 8. Review.

Insights into the key roles of epigenetics in matrix macromolecules-associated wound healing.

Piperigkou Z, Götte M, Theocharis AD, Karamanos NK.

Adv Drug Deliv Rev. 2018 Apr;129:16-36. doi: 10.1016/j.addr.2017.10.008. Epub 2017 Oct 24. Review.

Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis.

Mavrogonatou E, Pratsinis H, Papadopoulou A, Karamanos NK, Kletsas D.

Matrix Biol. 2019 Jan;75-76:27-42. doi: 10.1016/j.matbio.2017.10.004. Epub 2017 Oct 21. Review.

Estrogen receptor beta as epigenetic mediator of miR-10b and miR-145 in mammary cancer.

Piperigkou Z, Franchi M, Götte M, Karamanos NK.

Matrix Biol. 2017 Dec;64:94-111. doi: 10.1016/j.matbio.2017.08.002. Epub 2017 Aug 8.

IGF-IR cooperates with ERα to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM molecules.

Afratis NA, Bouris P, Skandalis SS, Multhaupt HA, Couchman JR, Theocharis AD, Karamanos NK.

Sci Rep. 2017 Jan 12;7:40138. doi: 10.1038/srep40138.

Matrix pathobiology-central roles for proteoglycans and heparanase in health and disease.

Karamanos NK.

FEBS J. 2017 Jan;284(1):7-9. doi: 10.1111/febs.13945.

Syndecans - key regulators of cell signaling and biological functions.

Afratis NA, Nikitovic D, Multhaupt HA, Theocharis AD, Couchman JR, Karamanos NK.

FEBS J. 2017 Jan;284(1):27-41. doi: 10.1111/febs.13940. Epub 2016 Nov 18. Review.

Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer.

Karousou E, Misra S, Ghatak S, Dobra K, Götte M, Vigetti D, Passi A, Karamanos NK, Skandalis SS.

Matrix Biol. 2017 May;59:3-22. doi: 10.1016/j.matbio.2016.10.001. Epub 2016 Oct 13. Review.

Data on the putative role of p53 in breast cancer cell adhesion: Technical information for adhesion assay.

Voudouri K, Nikitovic D, Berdiaki A, Tsiaoussis J, Kletsas D, Karamanos NK, Tzanakakis GN.

Data Brief. 2016 Sep 30;9:568-572. eCollection 2016 Dec.

Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast stromal fibroblasts: the role of TGF-β.

Liakou E, Mavrogonatou E, Pratsinis H, Rizou S, Evangelou K, Panagiotou PN, Karamanos NK, Gorgoulis VG, Kletsas D.

Aging (Albany NY). 2016 Aug;8(8):1650-69. doi: 10.18632/aging.100989.

IGF-I/EGF and E2 signaling crosstalk through IGF-IR conduit point affects breast cancer cell adhesion.

Voudouri K, Nikitovic D, Berdiaki A, Kletsas D, Karamanos NK, Tzanakakis GN.

Matrix Biol. 2016 Dec;56:95-113. doi: 10.1016/j.matbio.2016.06.005. Epub 2016 Jun 25.

Estrogen receptor beta modulates breast cancer cells functional properties, signaling and expression of matrix molecules.

Piperigkou Z, Bouris P, Onisto M, Franchi M, Kletsas D, Theocharis AD, Karamanos NK.

Matrix Biol. 2016 Dec;56:4-23. doi: 10.1016/j.matbio.2016.05.003. Epub 2016 May 11.

Synthesis and antiproliferative activity of two diastereomeric lignan amides serving as dimeric caffeic acid-l-DOPA hybrids.

Magoulas GE, Rigopoulos A, Piperigkou Z, Gialeli C, Karamanos NK, Takis PG, Troganis AN, Chrissanthopoulos A, Maroulis G, Papaioannou D.

Bioorg Chem. 2016 Jun;66:132-44. doi: 10.1016/j.bioorg.2016.04.003. Epub 2016 Apr 23.

Investigation on Toxicity and Teratogenicity in Rats of a Retinoid-Polyamine Conjugate with Potent Anti-Inflammatory Properties.

Petridis T, Giannakopoulou D, Stamatopoulou V, Grafanaki K, Kostopoulos CG, Papadaki H, Malavaki CJ, Karamanos NK, Douroumi S, Papachristou D, Magoulas GE, Papaioannou D, Drainas D.

Birth Defects Res B Dev Reprod Toxicol. 2016 Feb;107(1):32-44. doi: 10.1002/bdrb.21170. Epub 2016 Jan 13.

Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines.

Korpetinou A, Papachristou DJ, Lampropoulou A, Bouris P, Labropoulou VT, Noulas A, Karamanos NK, Theocharis AD.

Biomed Res Int. 2015;2015:690721. doi: 10.1155/2015/690721. Epub 2015 Oct 25.

Extracellular matrix structure.

Theocharis AD, Skandalis SS, Gialeli C, Karamanos NK.

Adv Drug Deliv Rev. 2016 Feb 1;97:4-27. doi: 10.1016/j.addr.2015.11.001. Epub 2015 Nov 10. Review.

Syndecan-1 alters heparan sulfate composition and signaling pathways in malignant mesothelioma.

Heidari-Hamedani G, Vivès RR, Seffouh A, Afratis NA, Oosterhof A, van Kuppevelt TH, Karamanos NK, Metintas M, Hjerpe A, Dobra K, Szatmári T.

Cell Signal. 2015 Oct;27(10):2054-67. doi: 10.1016/j.cellsig.2015.07.017. Epub 2015 Jul 23. Erratum in: Cell Signal. 2015 Dec;27(12):2599-601.

Increased β-glucuronidase activity in bronchoalveolar lavage fluid of children with bacterial lung infection: A case-control study.

Panagiotopoulou EC, Fouzas S, Douros K, Triantaphyllidou IE, Malavaki C, Priftis KN, Karamanos NK, Anthracopoulos MB.

Respirology. 2015 Nov;20(8):1248-54. doi: 10.1111/resp.12596. Epub 2015 Jul 14.

Insights into the key roles of proteoglycans in breast cancer biology and translational medicine.

Theocharis AD, Skandalis SS, Neill T, Multhaupt HA, Hubo M, Frey H, Gopal S, Gomes A, Afratis N, Lim HC, Couchman JR, Filmus J, Sanderson RD, Schaefer L, Iozzo RV, Karamanos NK.

Biochim Biophys Acta. 2015 Apr;1855(2):276-300. doi: 10.1016/j.bbcan.2015.03.006. Epub 2015 Mar 28. Review.

Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells.

Bouris P, Skandalis SS, Piperigkou Z, Afratis N, Karamanou K, Aletras AJ, Moustakas A, Theocharis AD, Karamanos NK.

Matrix Biol. 2015 Apr;43:42-60. doi: 10.1016/j.matbio.2015.02.008. Epub 2015 Feb 27.

 Anti-TNFα treatment decreases the previously increased serum Indian Hedgehog levels in patients with ankylosing spondylitis and affects the expression of functional Hedgehog pathway target genes.

Daoussis D, Filippopoulou A, Liossis SN, Sirinian C, Klavdianou K, Bouris P, Karamanos NK, Andonopoulos AP.

Semin Arthritis Rheum. 2015 Jun;44(6):646-51. doi: 10.1016/j.semarthrit.2015.01.004. Epub 2015 Jan 23.

Synthesis and evaluation of anticancer activity in cells of novel stoichiometric pegylated fullerene-doxorubicin conjugates.

Magoulas GE, Bantzi M, Messari D, Voulgari E, Gialeli C, Barbouri D, Giannis A, Karamanos NK, Papaioannou D, Avgoustakis K.

Pharm Res. 2015 May;32(5):1676-93. doi: 10.1007/s11095-014-1566-1. Epub 2014 Nov 8.

Cell-matrix interactions: focus on proteoglycan-proteinase interplay and pharmacological targeting in cancer.

Theocharis AD, Gialeli C, Bouris P, Giannopoulou E, Skandalis SS, Aletras AJ, Iozzo RV, Karamanos NK.

FEBS J. 2014 Nov;281(22):5023-42. doi: 10.1111/febs.12927. Epub 2014 Nov 6. Review.

Validated capillary electrophoretic assays for disaccharide composition analysis of galactosaminoglycans in biologic samples and drugs/nutraceuticals.

Asimakopoulou AP, Malavaki C, Afratis NA, Theocharis AD, Lamari FN, Karamanos NK.

Methods Mol Biol. 2015;1229:129-41. doi: 10.1007/978-1-4939-1714-3_13.

Novel insights into matrix pathobiology regulatory mechanisms in health and disease.

Karamanos NK, Passi A.

FEBS J. 2014 Nov;281(22):4978-9. doi: 10.1111/febs.13106. Epub 2014 Nov 6. No abstract available.

Preparation and toxicological assessment of functionalized carbon nanotube-polymer hybrids.

Koromilas ND, Lainioti GCh, Gialeli C, Barbouri D, Kouravelou KB, Karamanos NK, Voyiatzis GA, Kallitsis JK.

PLoS One. 2014 Sep 17;9(9):e107029. doi: 10.1371/journal.pone.0107029. eCollection 2014.

Advances and advantages of nanomedicine in the pharmacological targeting of hyaluronan-CD44 interactions and signaling in cancer.

Skandalis SS, Gialeli C, Theocharis AD, Karamanos NK.

Adv Cancer Res. 2014;123:277-317. doi: 10.1016/B978-0-12-800092-2.00011-3. Review.

Isothiocyanate analogs targeting CD44 receptor as an effective strategy against colon cancer.

Misra S, Ghatak S, Vyas A, O'Brien P, Markwald RR, Khetmalas M, Hascall VC, McCarthy JB, Karamanos NK, Tammi MI, Tammi RH, Prestwitch GD, Padhye S.

Med Chem Res. 2014 Aug 1;23(8):3836-3851.

Matrix-mediated cell behaviour and properties.

Karamanos NK.

Biochim Biophys Acta. 2014 Aug;1840(8):2385. doi: 10.1016/j.bbagen.2014.05.015. No abstract available.

FACE analysis as a fast and reliable methodology to monitor the sulfation and total amount of chondroitin sulfate in biological samples of clinical importance.

Karousou E, Asimakopoulou A, Monti L, Zafeiropoulou V, Afratis N, Gartaganis P, Rossi A, Passi A, Karamanos NK.

Molecules. 2014 Jun 12;19(6):7959-80. doi: 10.3390/molecules19067959.

EGFR and HER2 exert distinct roles on colon cancer cell functional properties and expression of matrix macromolecules.

Ellina MI, Bouris P, Aletras AJ, Theocharis AD, Kletsas D, Karamanos NK.

Biochim Biophys Acta. 2014 Aug;1840(8):2651-61. doi: 10.1016/j.bbagen.2014.04.019. Epub 2014 May 2.

The differential proliferative response of fetal and adult human skin fibroblasts to TGF-β is retained when cultured in the presence of fibronectin or collagen.

Armatas AA, Pratsinis H, Mavrogonatou E, Angelopoulou MT, Kouroumalis A, Karamanos NK, Kletsas D.

Biochim Biophys Acta. 2014 Aug;1840(8):2635-42. doi: 10.1016/j.bbagen.2014.04.004. Epub 2014 Apr 13.

EMMPRIN/CD147-encriched membrane vesicles released from malignant human testicular germ cells increase MMP production through tumor-stroma interaction.

Milia-Argeiti E, Mourah S, Vallée B, Huet E, Karamanos NK, Theocharis AD, Menashi S.

Biochim Biophys Acta. 2014 Aug;1840(8):2581-8. doi: 10.1016/j.bbagen.2014.02.026. Epub 2014 Mar 6.

Dynamic interplay between breast cancer cells and normal endothelium mediates the expression of matrix macromolecules, proteasome activity and functional properties of endothelial cells.

Gialeli Ch, Viola M, Barbouri D, Kletsas D, Passi A, Karamanos NK.

Biochim Biophys Acta. 2014 Aug;1840(8):2549-59. doi: 10.1016/j.bbagen.2014.02.019. Epub 2014 Feb 26.

Syndecans as modulators and potential pharmacological targets in cancer progression.

Barbouri D, Afratis N, Gialeli C, Vynios DH, Theocharis AD, Karamanos NK.

Front Oncol. 2014 Feb 3;4:4. doi: 10.3389/fonc.2014.00004. eCollection 2014. Review.

Heparan sulfate proteoglycans and heparin regulate melanoma cell functions.

Nikitovic D, Mytilinaiou M, Berdiaki A, Karamanos NK, Tzanakakis GN.

Biochim Biophys Acta. 2014 Aug;1840(8):2471-81. doi: 10.1016/j.bbagen.2014.01.031. Epub 2014 Jan 28. Review.

Serglycin: at the crossroad of inflammation and malignancy.

Korpetinou A, Skandalis SS, Labropoulou VT, Smirlaki G, Noulas A, Karamanos NK, Theocharis AD.

Front Oncol. 2014 Jan 13;3:327. doi: 10.3389/fonc.2013.00327. eCollection 2014 Jan 13. Review.

Serglycin is implicated in the promotion of aggressive phenotype of breast cancer cells.

Korpetinou A, Skandalis SS, Moustakas A, Happonen KE, Tveit H, Prydz K, Labropoulou VT, Giannopoulou E, Kalofonos HP, Blom AM, Karamanos NK, Theocharis AD.

PLoS One. 2013 Oct 31;8(10):e78157. doi: 10.1371/journal.pone.0078157. eCollection 2013.

The roles of hyaluronan/RHAMM/CD44 and their respective interactions along the insidious pathways of fibrosarcoma progression.

Nikitovic D, Kouvidi K, Karamanos NK, Tzanakakis GN.

Biomed Res Int. 2013;2013:929531. doi: 10.1155/2013/929531. Epub 2013 Sep 5. Review.

Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: focus on the role and impact of proteoglycans.

Skandalis SS, Afratis N, Smirlaki G, Nikitovic D, Theocharis AD, Tzanakakis GN, Karamanos NK.

Matrix Biol. 2014 Apr;35:182-93. doi: 10.1016/j.matbio.2013.09.002. Epub 2013 Sep 21. Review.

Lumican affects tumor cell functions, tumor-ECM interactions, angiogenesis and inflammatory response.

Nikitovic D, Papoutsidakis A, Karamanos NK, Tzanakakis GN.

Matrix Biol. 2014 Apr;35:206-14. doi: 10.1016/j.matbio.2013.09.003. Epub 2013 Sep 21. Review.

PDGF/PDGFR signaling and targeting in cancer growth and progression: Focus on tumor microenvironment and cancer-associated fibroblasts.

Gialeli C, Nikitovic D, Kletsas D, Theocharis AD, Tzanakakis GN, Karamanos NK.

Curr Pharm Des. 2014;20(17):2843-8. Review.

Expression of syndecan-4 and correlation with metastatic potential in testicular germ cell tumours.

Labropoulou VT, Skandalis SS, Ravazoula P, Perimenis P, Karamanos NK, Kalofonos HP, Theocharis AD.

Biomed Res Int. 2013;2013:214864. doi: 10.1155/2013/214864. Epub 2013 Jun 15.

The effect of synbiotics on acute radiation-induced diarrhea and its association with mucosal inflammatory and adaptive responses in rats.

Spyropoulos BG, Theodoropoulos G, Misiakos EP, Stoidis CN, Zapatis H, Diamantopoulou K, Gialeli C, Karamanos NK, Karatzas G, Machairas A, Fotiadis C, Zografos GC, Kelekis N, Kouloulias V.

Dig Dis Sci. 2013 Sep;58(9):2487-98. doi: 10.1007/s10620-013-2700-3. Epub 2013 May 22.

Could growth factor-mediated extracellular matrix deposition and degradation offer the ground for directed pharmacological targeting in fibrosarcoma?

Nikitovic D, Berdiaki A, Banos A, Tsatsakis A, Karamanos NK, Tzanakakis GN.

Curr Med Chem. 2013;20(23):2868-80. Review.

Efficacy versus safety concerns for aerosol chemotherapy in non-small-cell lung cancer: a future dilemma for micro-oncology.

Darwiche K, Zarogoulidis P, Karamanos NK, Domvri K, Chatzaki E, Constantinidis TC, Kakolyris S, Zarogoulidis K.

Future Oncol. 2013 Apr;9(4):505-25. doi: 10.2217/fon.12.205. Review.

Special issue: Proteoglycans: signaling, targeting and therapeutics: introduction.

Karamanos NK, Linhardt RJ.

FEBS J. 2013 May;280(10):2119. doi: 10.1111/febs.12262. Epub 2013 Apr 18.

New insights into the pathobiology of Down syndrome--hyaluronan synthase-2 overexpression is regulated by collagen VI α2 chain.

Karousou E, Stachtea X, Moretto P, Viola M, Vigetti D, D'Angelo ML, Raio L, Ghezzi F, Pallotti F, De Luca G, Karamanos NK, Passi A.

FEBS J. 2013 May;280(10):2418-30. doi: 10.1111/febs.12220. Epub 2013 Mar 28.

Preclinical evaluation of zoledronate using an in vitro mimetic cellular model for breast cancer metastatic bone disease.

Dedes PG, Kanakis I, Gialeli Ch, Theocharis AD, Tsegenidis T, Kletsas D, Tzanakakis GN, Karamanos NK.

Biochim Biophys Acta. 2013 Jun;1830(6):3625-34. doi: 10.1016/j.bbagen.2013.01.020. Epub 2013 Feb 5.

Cell-surface serglycin promotes adhesion of myeloma cells to collagen type I and affects the expression of matrix metalloproteinases.

Skliris A, Labropoulou VT, Papachristou DJ, Aletras A, Karamanos NK, Theocharis AD.

FEBS J. 2013 May;280(10):2342-52. doi: 10.1111/febs.12179. Epub 2013 Mar 1.

Imatinib as a key inhibitor of the platelet-derived growth factor receptor mediated expression of cell surface heparan sulfate proteoglycans and functional properties of breast cancer cells.

Malavaki CJ, Roussidis AE, Gialeli C, Kletsas D, Tsegenidis T, Theocharis AD, Tzanakakis GN, Karamanos NK.

FEBS J. 2013 May;280(10):2477-89. doi: 10.1111/febs.12163. Epub 2013 Feb 27.

Evaluation of the coordinated actions of estrogen receptors with epidermal growth factor receptor and insulin-like growth factor receptor in the expression of cell surface heparan sulfate proteoglycans and cell motility in breast cancer cells.

Tsonis AI, Afratis N, Gialeli C, Ellina MI, Piperigkou Z, Skandalis SS, Theocharis AD, Tzanakakis GN, Karamanos NK.

FEBS J. 2013 May;280(10):2248-59. doi: 10.1111/febs.12162. Epub 2013 Feb 27.

Syndecan-2 is a key regulator of transforming growth factor beta 2/Smad2-mediated adhesion in fibrosarcoma cells.

Mytilinaiou M, Bano A, Nikitovic D, Berdiaki A, Voudouri K, Kalogeraki A, Karamanos NK, Tzanakakis GN.

IUBMB Life. 2013 Feb;65(2):134-43. doi: 10.1002/iub.1112. Epub 2013 Jan 7.

Vectors for inhaled gene therapy in lung cancer. Application for nano oncology and safety of bio nanotechnology.

Zarogouldis P, Karamanos NK, Porpodis K, Domvri K, Huang H, Hohenforst-Schimdt W, Goldberg EP, Zarogoulidis K.

Int J Mol Sci. 2012;13(9):10828-62. doi: 10.3390/ijms130910828. Epub 2012 Aug 29. Review.

Inhaled chemotherapy in lung cancer: safety concerns of nanocomplexes delivered.

Zarogoulidis P, Giraleli C, Karamanos NK.

Ther Deliv. 2012 Sep;3(9):1021-3. No abstract available.

Expression of matrix macromolecules and functional properties of EGF-responsive colon cancer cells are inhibited by panitumumab.

Gialeli Ch, Theocharis AD, Kletsas D, Tzanakakis GN, Karamanos NK.

Invest New Drugs. 2013 Jun;31(3):516-24. doi: 10.1007/s10637-012-9875-x. Epub 2012 Sep 6.

Expression of matrix macromolecules and functional properties of breast cancer cells are modulated by the bisphosphonate zoledronic acid.

Dedes PG, Gialeli Ch, Tsonis AI, Kanakis I, Theocharis AD, Kletsas D, Tzanakakis GN, Karamanos NK.

Biochim Biophys Acta. 2012 Dec;1820(12):1926-39. doi: 10.1016/j.bbagen.2012.07.013. Epub 2012 Aug 3.

The biology of small leucine-rich proteoglycans in bone pathophysiology.

Nikitovic D, Aggelidakis J, Young MF, Iozzo RV, Karamanos NK, Tzanakakis GN.

J Biol Chem. 2012 Oct 5;287(41):33926-33. doi: 10.1074/jbc.R112.379602. Epub 2012 Aug 9. Review.

Imbalance of MMP-2 and MMP-9 expression versus TIMP-1 and TIMP-2 reflects increased invasiveness of human testicular germ cell tumours.

Milia-Argeiti E, Huet E, Labropoulou VT, Mourah S, Fenichel P, Karamanos NK, Menashi S, Theocharis AD.

Int J Androl. 2012 Dec;35(6):835-44. doi: 10.1111/j.1365-2605.2012.01289.x. Epub 2012 Jun 19.

Insights into targeting colon cancer cell fate at the level of proteoglycans / glycosaminoglycans.

Nikitovic D, Chatzinikolaou G, Tsiaoussis J, Tsatsakis A, Karamanos NK, Tzanakakis GN.

Curr Med Chem. 2012;19(25):4247-58.

Targeting the tumor proteasome as a mechanism to control the synthesis and bioactivity of matrix macromolecules.

Skandalis SS, Aletras AJ, Gialeli C, Theocharis AD, Afratis N, Tzanakakis GN, Karamanos NK.

Curr Mol Med. 2012 Sep;12(8):1068-82. Review.

An extracellular Staphylococcus epidermidis polysaccharide: relation to Polysaccharide Intercellular Adhesin and its implication in phagocytosis.

Spiliopoulou AI, Krevvata MI, Kolonitsiou F, Harris LG, Wilkinson TS, Davies AP, Dimitracopoulos GO, Karamanos NK, Mack D, Anastassiou ED.

BMC Microbiol. 2012 May 17;12:76. doi: 10.1186/1471-2180-12-76.

Glycosaminoglycans: key players in cancer cell biology and treatment.

Afratis N, Gialeli C, Nikitovic D, Tsegenidis T, Karousou E, Theocharis AD, Pavão MS, Tzanakakis GN, Karamanos NK.

FEBS J. 2012 Apr;279(7):1177-97. doi: 10.1111/j.1742-4658.2012.08529.x. Epub 2012 Mar 12. Review.

Glycosaminoglycans: from "cellular glue" to novel therapeutical agents.

Karamanos NK, Tzanakakis GN.

Curr Opin Pharmacol. 2012 Apr;12(2):220-2. doi: 10.1016/j.coph.2011.12.003. Epub 2012 Feb 9. No abstract available.

Wild blueberry (V. angustifolium)-enriched diets alter aortic glycosaminoglycan profile in the spontaneously hypertensive rat.

Kristo AS, Malavaki CJ, Lamari FN, Karamanos NK, Klimis-Zacas D.

J Nutr Biochem. 2012 Aug;23(8):961-5. doi: 10.1016/j.jnutbio.2011.05.002. Epub 2011 Sep 16.

Role of receptor for hyaluronic acid-mediated motility (RHAMM) in low molecular weight hyaluronan (LMWHA)-mediated fibrosarcoma cell adhesion.

Kouvidi K, Berdiaki A, Nikitovic D, Katonis P, Afratis N, Hascall VC, Karamanos NK, Tzanakakis GN.

J Biol Chem. 2011 Nov 4;286(44):38509-20. doi: 10.1074/jbc.M111.275875. Epub 2011 Sep 13.

Low molecular weight heparin inhibits melanoma cell adhesion and migration through a PKCa/JNK signaling pathway inducing actin cytoskeleton changes.

Chalkiadaki G, Nikitovic D, Katonis P, Berdiaki A, Tsatsakis A, Kotsikogianni I, Karamanos NK, Tzanakakis GN.

Cancer Lett. 2011 Dec 22;312(2):235-44. doi: 10.1016/j.canlet.2011.08.016. Epub 2011 Aug 22.

Parathyroid hormone affects the fibroblast growth factor-proteoglycan signaling axis to regulate osteosarcoma cell migration.

Datsis GA, Berdiaki A, Nikitovic D, Mytilineou M, Katonis P, Karamanos NK, Tzanakakis GN.

FEBS J. 2011 Oct;278(19):3782-92. doi: 10.1111/j.1742-4658.2011.08300.x. Epub 2011 Sep 8.

Versican but not decorin accumulation is related to malignancy in mammographically detected high density and malignant-appearing microcalcifications in non-palpable breast carcinomas.

Skandalis SS, Labropoulou VT, Ravazoula P, Likaki-Karatza E, Dobra K, Kalofonos HP, Karamanos NK, Theocharis AD.

BMC Cancer. 2011 Jul 26;11:314. doi: 10.1186/1471-2407-11-314.

Pathophysiology and pharmacological targeting of tumor-induced bone disease: current status and emerging therapeutic interventions.

Labropoulou VT, Theocharis AD, Symeonidis A, Skandalis SS, Karamanos NK, Kalofonos HP.

Curr Med Chem. 2011;18(11):1584-98. Review.

Lumican regulates osteosarcoma cell adhesion by modulating TGFβ2 activity.

Nikitovic D, Chalkiadaki G, Berdiaki A, Aggelidakis J, Katonis P, Karamanos NK, Tzanakakis GN.

Int J Biochem Cell Biol. 2011 Jun;43(6):928-35. doi: 10.1016/j.biocel.2011.03.008. Epub 2011 Mar 21.

Hyaluronan-CD44 interactions as potential targets for cancer therapy.

Misra S, Heldin P, Hascall VC, Karamanos NK, Skandalis SS, Markwald RR, Ghatak S.

FEBS J. 2011 May;278(9):1429-43. doi: 10.1111/j.1742-4658.2011.08071.x. Epub 2011 Mar 25. Review.

Heparin plays a key regulatory role via a p53/FAK-dependent signaling in melanoma cell adhesion and migration.

Chalkiadaki G, Nikitovic D, Berdiaki A, Katonis P, Karamanos NK, Tzanakakis GN.

IUBMB Life. 2011 Feb;63(2):109-19. doi: 10.1002/iub.421. Epub 2011 Feb 24.

Syntheses, antiproliferative activity and theoretical characterization of acitretin-type retinoids with changes in the lipophilic part.

Magoulas GE, Bariamis SE, Athanassopoulos CM, Haskopoulos A, Dedes PG, Krokidis MG, Karamanos NK, Kletsas D, Papaioannou D, Maroulis G.

Eur J Med Chem. 2011 Feb;46(2):721-37. doi: 10.1016/j.ejmech.2010.12.008. Epub 2010 Dec 14.

Heparan sulfate: biological significance, tools for biochemical analysis and structural characterization.

Malavaki CJ, Theocharis AD, Lamari FN, Kanakis I, Tsegenidis T, Tzanakakis GN, Karamanos NK.

Biomed Chromatogr. 2011 Jan;25(1-2):11-20. doi: 10.1002/bmc.1536. Review.

Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting.

Gialeli C, Theocharis AD, Karamanos NK.

FEBS J. 2011 Jan;278(1):16-27. doi: 10.1111/j.1742-4658.2010.07919.x. Epub 2010 Nov 19. Review.

Monitoring serum chondroitin sulfate levels in patients submitted to coronary artery bypass surgery.

Karangelis D, Asimakopoulou A, Kanakis I, Tagarakis GI, Koufakis T, Triposkiadis F, Tsilimingas N, Karamanos NK.

Biomed Chromatogr. 2011 Jul;25(7):748-50. doi: 10.1002/bmc.1533. Epub 2010 Oct 20.

Glycosaminoglycans as key molecules in atherosclerosis: the role of versican and hyaluronan.

Karangelis DE, Kanakis I, Asimakopoulou AP, Karousou E, Passi A, Theocharis AD, Triposkiadis F, Tsilimingas NB, Karamanos NK.

Curr Med Chem. 2010;17(33):4018-26. Review.

Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting.

Theocharis AD, Skandalis SS, Tzanakakis GN, Karamanos NK.

FEBS J. 2010 Oct;277(19):3904-23. doi: 10.1111/j.1742-4658.2010.07800.x. Epub 2010 Aug 31. Review.

Crocetin inhibits invasiveness of MDA-MB-231 breast cancer cells via downregulation of matrix metalloproteinases.

Chryssanthi DG, Dedes PG, Karamanos NK, Cordopatis P, Lamari FN.

Planta Med. 2011 Jan;77(2):146-51. doi: 10.1055/s-0030-1250178. Epub 2010 Aug 27.

A modified protocol for isolation and purity evaluation of a staphylococcal acidic polysaccharide by chromatography and capillary electrophoresis.

Krevvata MI, Afratis N, Spiliopoulou A, Malavaki CJ, Kolonitsiou F, Anastassiou E, Karamanos NK.

Biomed Chromatogr. 2011 May;25(5):531-4. doi: 10.1002/bmc.1490. Epub 2010 Aug 23.

Parathyroid hormone (PTH) peptides through the regulation of hyaluronan metabolism affect osteosarcoma cell migration.

Berdiaki A, Datsis GA, Nikitovic D, Tsatsakis A, Katonis P, Karamanos NK, Tzanakakis GN.

IUBMB Life. 2010 May;62(5):377-86. doi: 10.1002/iub.320.

The role of oligodendrocytes in the molecular pathobiology and potential molecular treatment of cervical spondylotic myelopathy.

Karadimas SK, Gialeli CH, Klironomos G, Tzanakakis GN, Panagiotopoulos E, Karamanos NK, Gatzounis G.

Curr Med Chem. 2010;17(11):1048-58. Review.

Tear analysis of ascorbic acid, uric acid and malondialdehyde with capillary electrophoresis.

Georgakopoulos CD, Lamari FN, Karathanasopoulou IN, Gartaganis VS, Pharmakakis NM, Karamanos NK.

Biomed Chromatogr. 2010 Aug;24(8):852-7. doi: 10.1002/bmc.1376.

Heparin regulates colon cancer cell growth through p38 mitogen-activated protein kinase signalling.

Chatzinikolaou G, Nikitovic D, Berdiaki A, Zafiropoulos A, Katonis P, Karamanos NK, Tzanakakis GN.

Cell Prolif. 2010 Feb;43(1):9-18. doi: 10.1111/j.1365-2184.2009.00649.x. Epub 2009 Oct 21.

Targeting epidermal growth factor receptor in solid tumors: critical evaluation of the biological importance of therapeutic monoclonal antibodies.

Gialeli Ch, Kletsas D, Mavroudis D, Kalofonos HP, Tzanakakis GN, Karamanos NK.

Curr Med Chem. 2009;16(29):3797-804. Review.

bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells.

Berdiaki A, Nikitovic D, Tsatsakis A, Katonis P, Karamanos NK, Tzanakakis GN.

Biochim Biophys Acta. 2009 Oct;1790(10):1258-65. doi: 10.1016/j.bbagen.2009.06.013. Epub 2009 Jul 3.

The impact of zoledronic acid therapy in survival of lung cancer patients with bone metastasis.

Zarogoulidis K, Boutsikou E, Zarogoulidis P, Eleftheriadou E, Kontakiotis T, Lithoxopoulou H, Tzanakakis G, Kanakis I, Karamanos NK.

Int J Cancer. 2009 Oct 1;125(7):1705-9. doi: 10.1002/ijc.24470.

Estradiol-estrogen receptor: a key interplay of the expression of syndecan-2 and metalloproteinase-9 in breast cancer cells.

Kousidou OCh, Berdiaki A, Kletsas D, Zafiropoulos A, Theocharis AD, Tzanakakis GN, Karamanos NK.

Mol Oncol. 2008 Oct;2(3):223-32. doi: 10.1016/j.molonc.2008.06.002. Epub 2008 Jun 18.

A comparative biochemical analysis of glycosaminoglycans and proteoglycans in human orthotopic and heterotopic bone.

Mania VM, Kallivokas AG, Malavaki C, Asimakopoulou AP, Kanakis J, Theocharis AD, Klironomos G, Gatzounis G, Mouzaki A, Panagiotopoulos E, Karamanos NK.

IUBMB Life. 2009 Apr;61(4):447-52. doi: 10.1002/iub.167.

Fibroblast growth factor-2 modulates melanoma adhesion and migration through a syndecan-4-dependent mechanism.

Chalkiadaki G, Nikitovic D, Berdiaki A, Sifaki M, Krasagakis K, Katonis P, Karamanos NK, Tzanakakis GN.

Int J Biochem Cell Biol. 2009 Jun;41(6):1323-31. doi: 10.1016/j.biocel.2008.11.008. Epub 2008 Dec 6.

Lumican, a small leucine-rich proteoglycan.

Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN.

IUBMB Life. 2008 Dec;60(12):818-23. doi: 10.1002/iub.131. Review.

Small tyrosine kinase inhibitors as key molecules in the expression of metalloproteinases by solid tumors.

Stahtea XN, Kousidou OCh, Roussidis AE, Tzanakakis GN, Karamanos NK.

Connect Tissue Res. 2008;49(3):211-4. doi: 10.1080/03008200802143307. Review.

Hyaluronan and chondroitin sulfate proteoglycans in the supramolecular organization of the mammalian vitreous body.

Theocharis DA, Skandalis SS, Noulas AV, Papageorgakopoulou N, Theocharis AD, Karamanos NK.

Connect Tissue Res. 2008;49(3):124-8. doi: 10.1080/03008200802148496. Review.

The biological role of chondroitin sulfate in cancer and chondroitin-based anticancer agents.

Asimakopoulou AP, Theocharis AD, Tzanakakis GN, Karamanos NK.

In Vivo. 2008 May-Jun;22(3):385-9. Review.

Glycosaminoglycan in cerebrum, cerebellum and brainstem of young sheep brain with particular reference to compositional and structural variations of chondroitin-dermatan sulfate and hyaluronan.

Kilia V, Skandalis SS, Theocharis AD, Theocharis DA, Karamanos NK, Papageorgakopoulou N.

Biomed Chromatogr. 2008 Sep;22(9):931-8. doi: 10.1002/bmc.1010.

Decorin-induced growth inhibition is overcome through protracted expression and activation of epidermal growth factor receptors in osteosarcoma cells.

Zafiropoulos A, Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN.

Mol Cancer Res. 2008 May;6(5):785-94. doi: 10.1158/1541-7786.MCR-07-0165.

Imatinib mesylate inhibits proliferation and exerts an antifibrotic effect in human breast stroma fibroblasts.

Gioni V, Karampinas T, Voutsinas G, Roussidis AE, Papadopoulos S, Karamanos NK, Kletsas D.

Mol Cancer Res. 2008 May;6(5):706-14. doi: 10.1158/1541-7786.MCR-07-0355.

Heparin--a unique stimulator of human colon cancer cells' growth.

Chatzinikolaou G, Nikitovic D, Asimakopoulou A, Tsatsakis A, Karamanos NK, Tzanakakis GN.

IUBMB Life. 2008 May;60(5):333-40. doi: 10.1002/iub.70.

Design, synthesis and cell growth inhibitory activity of a series of novel aminosubstituted xantheno[1,2-d]imidazoles in breast cancer cells.

Kostakis IK, Pouli N, Marakos P, Kousidou OCh, Roussidis A, Tzanakakis GN, Karamanos NK.

Bioorg Med Chem. 2008 Mar 15;16(6):3445-55. doi: 10.1016/j.bmc.2007.03.003. Epub 2007 Mar 7.

Protein tyrosine kinase and estrogen receptor-dependent pathways regulate the synthesis and distribution of glycosaminoglycans/proteoglycans produced by two human colon cancer cell lines.

Chatzinikolaou G, Nikitovic D, Stathopoulos EN, Velegrakis GA, Karamanos NK, Tzanakakis GN.

Anticancer Res. 2007 Nov-Dec;27(6B):4101-6.

Lumican expression is positively correlated with the differentiation and negatively with the growth of human osteosarcoma cells.

Nikitovic D, Berdiaki A, Zafiropoulos A, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN.

FEBS J. 2008 Jan;275(2):350-61. Epub 2007 Dec 17.

Capillary electrophoresis for the quality control of chondroitin sulfates in raw materials and formulations.

Malavaki CJ, Asimakopoulou AP, Lamari FN, Theocharis AD, Tzanakakis GN, Karamanos NK.

Anal Biochem. 2008 Mar 1;374(1):213-20. Epub 2007 Nov 9.

Regulation of hyaluronan and versican deposition by growth factors in fibrosarcoma cell lines.

Berdiaki A, Zafiropoulos A, Fthenou E, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN.

Biochim Biophys Acta. 2008 Feb;1780(2):194-202. Epub 2007 Oct 17.

Chondroitin sulfate prevents platelet derived growth factor-mediated phosphorylation of PDGF-Rbeta in normal human fibroblasts severely impairing mitogenic responses.

Fthenou E, Zafiropoulos A, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN.

J Cell Biochem. 2008 Apr 15;103(6):1866-76.

Imatinib inhibits colorectal cancer cell growth and suppresses stromal-induced growth stimulation, MT1-MMP expression and pro-MMP2 activation.

Stahtea XN, Roussidis AE, Kanakis I, Tzanakakis GN, Chalkiadakis G, Mavroudis D, Kletsas D, Karamanos NK.

Int J Cancer. 2007 Dec 15;121(12):2808-14.

Chondroitin sulfate and heparan sulfate-containing proteoglycans are both partners and targets of basic fibroblast growth factor-mediated proliferation in human metastatic melanoma cell lines.

Nikitovic D, Assouti M, Sifaki M, Katonis P, Krasagakis K, Karamanos NK, Tzanakakis GN.

Int J Biochem Cell Biol. 2008;40(1):72-83. Epub 2007 Jul 30.

Inhibition of breast cancer cell proliferation by style constituents of different Crocus species.

Chryssanthi DG, Lamari FN, Iatrou G, Pylara A, Karamanos NK, Cordopatis P.

Anticancer Res. 2007 Jan-Feb;27(1A):357-62.

The importance of c-Kit and PDGF receptors as potential targets for molecular therapy in breast cancer.

Roussidis AE, Theocharis AD, Tzanakakis GN, Karamanos NK.

Curr Med Chem. 2007;14(7):735-43. Review.

Design, synthesis, and evaluation of the antiproliferative activity of a series of novel fused xanthenone aminoderivatives in human breast cancer cells.

Giannouli V, Kostakis IK, Pouli N, Marakos P, Kousidou OCh, Tzanakakis GN, Karamanos NK.

J Med Chem. 2007 Apr 5;50(7):1716-9. Epub 2007 Mar 3.

Expression and distribution of N-acetyl and N-glycolylneuraminic acids in secreted and cell-associated glycoconjugates by two human osteosarcoma cell lines.

Tzanakakis GN, Nikitovic D, Katonis P, Kanakis I, Karamanos NK.

Biomed Chromatogr. 2007 Apr;21(4):406-9.

Chondroitin sulfate as a key molecule in the development of atherosclerosis and cancer progression.

Theocharis AD, Tsolakis I, Tzanakakis GN, Karamanos NK.

Adv Pharmacol. 2006;53:281-95. Review. No abstract available.

Structure of chondroitin sulfate.

Lamari FN, Karamanos NK.

Adv Pharmacol. 2006;53:33-48. Review. No abstract available.

Gonadotropin-releasing hormone analogues alter gene expression of metalloproteinases and their tissue inhibitors in human breast cancer epithelial cells.

Lamari FN, Zompra AA, Pateraki E, Kousidou OC, Magafa V, Karamanos NK, Cordopatis P.

Anticancer Res. 2006 Nov-Dec;26(6B):4615-21.

Versican but not decorin accumulation is related to metastatic potential and neovascularization in testicular germ cell tumours.

Labropoulou VT, Theocharis AD, Ravazoula P, Perimenis P, Hjerpe A, Karamanos NK, Kalofonos HP.

Histopathology. 2006 Dec;49(6):582-93.

Design and synthesis of new pyranoxanthenones bearing a nitro group or an aminosubstituted side chain on the pyran ring. Evaluation of their growth inhibitory activity in breast cancer cells.

Kolokythas G, Kostakis IK, Pouli N, Marakos P, Kousidou OCh, Tzanakakis GN, Karamanos NK.

Eur J Med Chem. 2007 Mar;42(3):307-19. Epub 2006 Dec 4.

Lumican, a small leucine-rich proteoglycan substituted with keratan sulfate chains is expressed and secreted by human melanoma cells and not normal melanocytes.

Sifaki M, Assouti M, Nikitovic D, Krasagakis K, Karamanos NK, Tzanakakis GN.

IUBMB Life. 2006 Oct;58(10):606-10.

Chondroitin sulfate A chains enhance platelet derived growth factor-mediated signalling in fibrosarcoma cells.

Fthenou E, Zafiropoulos A, Tsatsakis A, Stathopoulos A, Karamanos NK, Tzanakakis GN.

Int J Biochem Cell Biol. 2006;38(12):2141-50. Epub 2006 Jul 5.

Dietary manganese affects the concentration, composition and sulfation pattern of heparan sulfate glycosaminoglycans in Sprague-Dawley rat aorta.

Kalea AZ, Lamari FN, Theocharis AD, Schuschke DA, Karamanos NK, Klimis-Zacas DJ.

Biometals. 2006 Oct;19(5):535-46.

Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro.

Theocharis AD, Seidel C, Borset M, Dobra K, Baykov V, Labropoulou V, Kanakis I, Dalas E, Karamanos NK, Sundan A, Hjerpe A.

J Biol Chem. 2006 Nov 17;281(46):35116-28. Epub 2006 Jul 26.

Metabolism and biochemical/physiological roles of chondroitin sulfates: analysis of endogenous and supplemental chondroitin sulfates in blood circulation.

Lamari FN, Theocharis AD, Asimakopoulou AP, Malavaki CJ, Karamanos NK.

Biomed Chromatogr. 2006 Jun-Jul;20(6-7):539-50. Review.

Identification of the commonest cystic fibrosis transmembrane regulator gene DeltaF508 mutation: evaluation of PCR--single-strand conformational polymorphism and polyacrylamide gel electrophoresis.

Kakavas KV, Noulas AV, Kanakis I, Bonanou S, Karamanos NK.

Biomed Chromatogr. 2006 Oct;20(10):1120-5.

Cartilage aggrecan undergoes significant compositional and structural alterations during laryngeal cancer.

Skandalis SS, Theocharis AD, Vynios DH, Papageorgakopoulou N, Hjerpe A, Karamanos NK, Theocharis DA.

Biochim Biophys Acta. 2006 Jul;1760(7):1046-53. Epub 2006 Mar 9.

Expression of TNF-alpha, IL-1beta, and IFN-gamma in Staphylococcus epidermidis slime-positive experimental endophthalmitis is closely related to clinical inflammatory scores.

Petropoulos IK, Vantzou CV, Lamari FN, Karamanos NK, Anastassiou ED, Pharmakakis NM.

Graefes Arch Clin Exp Ophthalmol. 2006 Oct;244(10):1322-8. Epub 2006 Mar 17.

Transforming growth factor-beta as a key molecule triggering the expression of versican isoforms v0 and v1, hyaluronan synthase-2 and synthesis of hyaluronan in malignant osteosarcoma cells.

Nikitovic D, Zafiropoulos A, Katonis P, Tsatsakis A, Theocharis AD, Karamanos NK, Tzanakakis GN.

IUBMB Life. 2006 Jan;58(1):47-53.

Effects of the natural isoflavonoid genistein on growth, signaling pathways and gene expression of matrix macromolecules by breast cancer cells.

Kousidou OCh, Tzanakakis GN, Karamanos NK.

Mini Rev Med Chem. 2006 Mar;6(3):331-7. Review.

Immunization with specific polysaccharide antigen reduces alterations in corneal proteoglycans during experimental slime-producing Staphylococcus epidermidis keratitis.

Georgakopoulos CD, Exarchou AM, Gartaganis SP, Kolonitsiou F, Anastassiou ED, Dimitracopoulos G, Hjerpe A, Theocharis AD, Karamanos NK.

Curr Eye Res. 2006 Feb;31(2):137-46.

Evaluation of modal damping factor as a diagnostic tool for osteoporosis and its relation with serum osteocalcin and collagen I N-telopeptide for monitoring the efficacy of alendronate in ovariectomized rats.

Christopoulou GE, Stavropoulou A, Anastassopoulos G, Panteliou SD, Papadaki E, Karamanos NK, Panagiotopoulos E.

J Pharm Biomed Anal. 2006 Jun 7;41(3):891-7. Epub 2006 Feb 20.

Alteration in serum leptin correlates with alterations in serum N-telopeptide of collagen type I and serum osteocalcin during the progression of osteoporosis in ovariectomized rats.

Stavropoulou A, Christopoulou GE, Anastassopoulos G, Panteliou SD, Lyritis GP, Spiliotis BE, Karamanos NK, Panagiotopoulos E, Lambiris E.

Clin Chem Lab Med. 2005;43(12):1359-65.

Synthesis and study of the electrophoretic behavior of mannan conjugates with cyclic peptide analogue of myelin basic protein using lysine-glycine linker.

Tselios TV, Lamari FN, Karathanasopoulou I, Katsara M, Apostolopoulos V, Pietersz GA, Matsoukas JM, Karamanos NK.

Anal Biochem. 2005 Dec 1;347(1):121-8. Epub 2005 Oct 3.

Determination and distribution of N-acetyl- and N-glycolylneuraminic acids in culture media and cell-associated glycoconjugates from human malignant mesothelioma and adenocarcinoma cells.

Tzanakakis GN, Syrokou A, Kanakis I, Karamanos NK.

Biomed Chromatogr. 2006 May;20(5):434-9.

Wild blueberry (Vaccinium angustifolium) consumption affects the composition and structure of glycosaminoglycans in Sprague-Dawley rat aorta.

Kalea AZ, Lamari FN, Theocharis AD, Cordopatis P, Schuschke DA, Karamanos NK, Klimis-Zacas DJ.

J Nutr Biochem. 2006 Feb;17(2):109-16. Epub 2005 Jun 20.

Effects of glycosaminoglycans on cell proliferation of normal osteoblasts and human osteosarcoma cells depend on their type and fine chemical compositions.

Nikitovic D, Zafiropoulos A, Tzanakakis GN, Karamanos NK, Tsatsakis AM.

Anticancer Res. 2005 Jul-Aug;25(4):2851-6.

Clinical value of bone remodelling markers in patients with bone metastases treated with zoledronic acid.

Pectasides D, Nikolaou M, Farmakis D, Kanakis I, Gaglia A, Kountourakis P, Karamanos NK, Economopoulos T, Raptis SA.

Anticancer Res. 2005 Mar-Apr;25(2B):1457-63.

Application of polyacrylamide gel electrophoresis of fluorophore-labeled saccharides for analysis of hyaluronan and chondroitin sulfate in human and animal tissues and cell cultures.

Karousou EG, Viola M, Genasetti A, Vigetti D, Luca GD, Karamanos NK, Passi A.

Biomed Chromatogr. 2005 Dec;19(10):761-5.

In vitro and in vivo antiresorptive effects of bisphosphonates in metastatic bone disease.

Kanakis I, Kousidou OCh, Karamanos NK.

In Vivo. 2005 Jan-Feb;19(1):311-8. Review.

Signal transduction by IL-2 and its receptors as target in treatment of rheumatoid arthritis.

Kozanidou VI, Theocharis AD, Georgiadis A, Voulgari PV, Drosos AA, Karamanos NK.

Curr Drug Targets Immune Endocr Metabol Disord. 2005 Mar;5(1):41-50. Review.

Genistein suppresses the invasive potential of human breast cancer cells through transcriptional regulation of metalloproteinases and their tissue inhibitors.

Kousidou OC, Mitropoulou TN, Roussidis AE, Kletsas D, Theocharis AD, Karamanos NK.

Int J Oncol. 2005 Apr;26(4):1101-9.

Expression of MMPs and TIMPs genes in human breast cancer epithelial cells depends on cell culture conditions and is associated with their invasive potential.

Kousidou OC, Roussidis AE, Theocharis AD, Karamanos NK.

Anticancer Res. 2004 Nov-Dec;24(6):4025-30.

Diagnostic value of bone remodeling markers in the diagnosis of bone metastases in patients with breast cancer.

Pectasides D, Farmakis D, Nikolaou M, Kanakis I, Kostopoulou V, Papaconstantinou I, Karamanos NK, Economopoulos T, Raptis SA.

J Pharm Biomed Anal. 2005 Feb 7;37(1):171-6.

The presence of a novel extracellular hyaluronidase in squid cranial cartilage.

Tsilemou A, Assouti M, Papageorgakopoulou N, Karamanos NK, Tsiganos CP, Vynios DH.

Biochimie. 2004 Aug;86(8):579-86.

Variations in content and structure of glycosaminoglycans of the vitreous gel from different mammalian species.

Noulas AV, Skandalis SS, Feretis E, Theocharis DA, Karamanos NK.

Biomed Chromatogr. 2004 Sep;18(7):457-61.

STI571 as a potent inhibitor of growth and invasiveness of human epithelial breast cancer cells.

Roussidis AE, Mitropoulou TN, Theocharis AD, Kiamouris C, Papadopoulos S, Kletsas D, Karamanos NK.

Anticancer Res. 2004 May-Jun;24(3a):1445-7.

IGF-I affects glycosaminoglycan/proteoglycan synthesis in breast cancer cells through tyrosine kinase-dependent and -independent pathways.

Mitropoulou TN, Theocharis AD, Nikitovic D, Karamanos NK, Tzanakakis GN.

Biochimie. 2004 Apr-May;86(4-5):251-9.

Determination and biological relevance of serum cross-linked type I collagen N-telopeptide and bone-specific alkaline phosphatase in breast metastatic cancer.

Kanakis I, Nikolaou M, Pectasides D, Kiamouris C, Karamanos NK.

J Pharm Biomed Anal. 2004 Mar 1;34(4):827-32.

Clara cell secretory protein: determination of serum levels by an enzyme immunoassay and its importance as an indicator of bronchial asthma in children.

Gioldassi XM, Papadimitriou H, Mikraki V, Karamanos NK.

J Pharm Biomed Anal. 2004 Mar 1;34(4):823-6.

Potential use of solid phase immunoassays in the diagnosis of coagulase-negative staphylococcal infections.

Lamari FN, Anastassiou ED, Kolonitsiou F, Dimitracopoulos G, Karamanos NK.

J Pharm Biomed Anal. 2004 Mar 1;34(4):803-10. Review.

Versican undergoes specific alterations in the fine molecular structure and organization in human aneurysmal abdominal aortas.

Theocharis AD, Tsolakis I, Hjerpe A, Karamanos NK.

Biomed Chromatogr. 2003 Sep;17(6):411-6.

Large matrix proteoglycans, versican and perlecan, are expressed and secreted by human leukemic monocytes.

Makatsori E, Lamari FN, Theocharis AD, Anagnostides S, Hjerpe A, Tsegenidis T, Karamanos NK.

Anticancer Res. 2003 Jul-Aug;23(4):3303-9.

Capillary electrophoresis: a tool for studying interactions of glycans/proteoglycans with growth factors.

Militsopoulou M, Lamari F, Karamanos NK.

J Pharm Biomed Anal. 2003 Aug 8;32(4-5):823-8.

Derivatization of carbohydrates for chromatographic, electrophoretic and mass spectrometric structure analysis.

Lamari FN, Kuhn R, Karamanos NK.

J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Aug 5;793(1):15-36. Review.

The effects of genistein on the synthesis and distribution of glycosaminoglycans/proteoglycans by two osteosarcoma cell lines depends on tyrosine kinase and the estrogen receptor density.

Nikitovic D, Tsatsakis AM, Karamanos NK, Tzanakakis GN.

Anticancer Res. 2003 Jan-Feb;23(1A):459-64.

Capillary electrophoresis and enzyme solid phase assay for examining the purity of a synthetic heparin proteoglycan-like conjugate and identifying binding to basic fibroblast growth factor.

Dimitrellos V, Lamari FN, Militsopoulou M, Kanakis I, Karamanos NK.

Biomed Chromatogr. 2003 Jan;17(1):42-7.

Laser-induced fluorescence as a powerful detection tool for capillary electrophoretic analysis of heparin/heparan sulfate disaccharides.

Militsopoulou M, Lecomte C, Bayle C, Couderc F, Karamanos NK.

Biomed Chromatogr. 2003 Jan;17(1):39-41.

Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cells.

Mitropoulou TN, Tzanakakis GN, Kletsas D, Kalofonos HP, Karamanos NK.

Int J Cancer. 2003 Mar 20;104(2):155-60.

Synthesis and expression of mRNA encoding for different versican splice variants is related to the aggregation of human epithelial mesothelioma cells.

Syrokou A, Dobra K, Tzanakakis GN, Hjerpe A, Karamanos NK.

Anticancer Res. 2002 Nov-Dec;22(6C):4157-62.

In vitro effects of genistein on the synthesis and distribution of glycosaminoglycans/proteoglycans by estrogen receptor-positive and -negative human breast cancer epithelial cells.

Mitropoulou TN, Tzanakakis GN, Nikitovic D, Tsatsakis A, Karamanos NK.

Anticancer Res. 2002 Sep-Oct;22(5):2841-6.

Inhibition of receptor tyrosine kinase-based signal transduction as specific target for cancer treatment.

Roussidis AE, Karamanos NK.

In Vivo. 2002 Nov-Dec;16(6):459-69. Review.

Compositional and structural alterations of chondroitin and dermatan sulfates during the progression of atherosclerosis and aneurysmal dilatation of the human abdominal aorta.

Theocharis AD, Theocharis DA, De Luca G, Hjerpe A, Karamanos NK.

Biochimie. 2002 Jul;84(7):667-74.

Advances in analysis of glycosaminoglycans: its application for the assessment of physiological and pathological states of connective tissues.

Vynios DH, Karamanos NK, Tsiganos CP.

J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Dec 5;781(1-2):21-38. Review.

Separation methods for sialic acids and critical evaluation of their biologic relevance.

Lamari FN, Karamanos NK.

J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Dec 5;781(1-2):3-19. Review.

Decreased biglycan expression and differential decorin localization in human abdominal aortic aneurysms.

Theocharis AD, Karamanos NK.

Atherosclerosis. 2002 Dec;165(2):221-30.

Ageing research in Greece.

Gonos ES, Agrafiotis D, Dontas AS, Efthimiopoulos S, Galaris D, Karamanos NK, Kletsas D, Kolettas E, Panayotou G, Pratsinis H, Sekeri-Pataryas KE, Simoes D, Sourlingas TG, Stathakos D, Stratigos AJ, Tavernarakis N, Trougakos IP, Tsiganos CP, Vynios DH.

Exp Gerontol. 2002 Jun;37(6):735-47.

Pig vitreous gel: macromolecular composition with particular reference to hyaluronan-binding proteoglycans.

Noulas AV, Theocharis AD, Feretis E, Papageorgakopoulou N, Karamanos NK, Theocharis DA.

Biochimie. 2002 Apr;84(4):295-302.

Levels of specific antibodies towards the major antigenic determinant of slime-producing Staphylococcus epidermidis determined by an enzyme immunoassay and their protective effect in experimental keratitis.

Georgakopoulos CD, Exarchou A, Koliopoulos JX, Gartaganis SP, Anastassiou ED, Kolonitsiou F, Lamari F, Karamanos NK, Dimitracopoulos G.

J Pharm Biomed Anal. 2002 Jun 20;29(1-2):255-62.

Determination of twelve heparin- and heparan sulfate-derived disaccharides as 2-aminoacridone derivatives by capillary zone electrophoresis using ultraviolet and laser-induced fluorescence detection.

Militsopoulou M, Lamari FN, Hjerpe A, Karamanos NK.

Electrophoresis. 2002 Apr;23(7-8):1104-9.

Identification of kappa and lambda chains of the major immunoglobulin G subclasses by capillary zone electrophoresis.

Katsougraki P, Heliopoulos J, Lamari F, Militsopoulou M, Anagnostides S, Piperidou H, Monos D, Karamanos NK.

Biomed Chromatogr. 2002 May;16(3):234-6.

A capillary zone electrophoresis method for determining N-acetylneuraminic acid in glycoproteins and blood sera.

Strousopoulou K, Militsopoulou M, Stagiannis K, Lamari FN, Karamanos NK.

Biomed Chromatogr. 2002 Apr;16(2):146-50.

Structure analysis of lipoglycans and lipoglycan-derived carbohydrates by capillary electrophoresis and mass spectrometry.

Lamari FN, Gioldassi XM, Mitropoulou TN, Karamanos NK.

Biomed Chromatogr. 2002 Apr;16(2):116-26. Review.

Analysis of glycosaminoglycan-derived disaccharides in biologic samples by capillary electrophoresis and protocol for sequencing glycosaminoglycans.

Lamari FN, Militsopoulou M, Mitropoulou TN, Hjerpe A, Karamanos NK.

Biomed Chromatogr. 2002 Apr;16(2):95-102. Review.

Isolation and characterization of matrix proteoglycans from human nasal cartilage. Compositional and structural comparison between normal and scoliotic tissues.

Theocharis AD, Karamanos NK, Papageorgakopoulou N, Tsiganos CP, Theocharis DA.

Biochim Biophys Acta. 2002 Jan 15;1569(1-3):117-26.

Increased aqueous humor basic fibroblast growth factor and hyaluronan levels in relation to the exfoliation syndrome and exfoliative glaucoma.

Gartaganis SP, Georgakopoulos CD, Exarchou AM, Mela EK, Lamari F, Karamanos NK.

Acta Ophthalmol Scand. 2001 Dec;79(6):572-5.

Effects of mitogens on synthesis and distribution of heparan and chondroitin sulphates by human leukemic B, T cells and monocytes studied by high-performance liquid chromatography and radiochemical detection.

Makatsori E, Tsegenidis T, Karamanos NK.

Biomed Chromatogr. 2001 Dec;15(8):534-8.

Capillary electrophoresis: a superior miniaturized tool for analysis of the mono-, di-, and oligosaccharide constituents of glycan moieties in proteoglycans.

Lamari F, Militsopoulou M, Gioldassi X, Karamanos NK.

Fresenius J Anal Chem. 2001 Sep;371(2):157-67. Review.

Synthesis and distribution of glycosaminoglycans in human leukemic B- and T-cells and monocytes studied using specific enzymic treatments and high-performance liquid chromatography.

Makatsori E, Karamanos NK, Papadogiannakis N, Hjerpe A, Anastassiou ED, Tsegenidis T.

Biomed Chromatogr. 2001 Oct;15(6):413-7.

Microemulsion electrokinetic capillary chromatography of sulfated disaccharides derived from glycosaminoglycans.

Mastrogianni O, Lamari F, Syrokou A, Militsopoulou M, Hjerpe A, Karamanos NK.

Electrophoresis. 2001 Aug;22(13):2743-5.

Identification of oligomeric domains within dermatan sulfate chains using differential enzymic treatments, derivatization with 2-aminoacridone and capillary electrophoresis.

Mitropoulou TN, Lamari F, Syrokou A, Hjerpe A, Karamanos NK.

Electrophoresis. 2001 Aug;22(12):2458-63.

Identification, quantification and fine structural characterization of glycosaminoglycans from uterine leiomyoma and normal myometrium.

Mitropoulou TN, Theocharis AD, Stagiannis KD, Karamanos NK.

Biochimie. 2001 Jun;83(6):529-36.

Intact and oligomeric glycosaminoglycans analyzed with capillary electrophoresis.

Karamanos NK, Hjerpe A.

Methods Mol Biol. 2001;171:193-8. No abstract available.

Disaccharide composition in glycosaminoglycans/proteoglycans analyzed by capillary zone electrophoresis.

Karamanos NK, Hjerpe A.

Methods Mol Biol. 2001;171:181-92. No abstract available.

Determination of malondialdehyde by capillary electrophoresis, application to human plasma and relation of its levels with prematurity.

Korizis KN, Exarchou A, Michalopoulos E, Georgakopoulos CD, Kolonitsiou F, Mantagos S, Gartaganis SP, Karamanos NK.

Biomed Chromatogr. 2001 Jun;15(4):287-91.

Application of capillary electrophoresis in the analysis of novel synthetic dideoxynucleoside analogues with potential anti-HIV activity.

Balayiannis G, Papaioannou D, Karamanos NK.

Biomed Chromatogr. 2001 Jun;15(4):271-3.

Immunoreactivity of 80-kDa peptidoglycan and teichoic acid-like substance of slime producing S. epidermidis and specificity of their antibodies studied by an enzyme immunoassay.

Kolonitsiou F, Syrokou A, Karamanos NK, Anastassiou ED, Dimitracopoulos G.

J Pharm Biomed Anal. 2001 Jan;24(3):429-36.

Human abdominal aortic aneurysm is characterized by decreased versican concentration and specific downregulation of versican isoform V(0).

Theocharis AD, Tsolakis I, Hjerpe A, Karamanos NK.

Atherosclerosis. 2001 Feb 1;154(2):367-76.

Immunochemical-based assays in the bioanalysis of immunoglobulins.

Lamari F, Anastassiou ED, Dimitracopoulos G, Karamanos NK.

J Pharm Biomed Anal. 2000 Nov;23(6):939-46. Review.

Capillary electrophoretic analysis of brimonidine in aqueous humor of the eye and blood sera and relation of its levels with intraocular pressure.

Tzovolou DN, Lamari F, Mela EK, Gartaganis SP, Karamanos NK.

Biomed Chromatogr. 2000 Aug;14(5):301-5.

Determination of slime-producing S. epidermidis specific antibodies in human immunoglobulin preparations and blood sera by an enzyme immunoassay: correlation of antibody titers with opsonic activity and application to preterm neonates.

Lamari F, Anastassiou ED, Stamokosta E, Photopoulos S, Xanthou M, Dimitracopoulos G, Karamanos NK.

J Pharm Biomed Anal. 2000 Aug 15;23(2-3):363-74.

Differentiation of mesothelioma cells is influenced by the expression of proteoglycans.

Dobra K, Andäng M, Syrokou A, Karamanos NK, Hjerpe A.

Exp Cell Res. 2000 Jul 10;258(1):12-22.

Monitoring of two intravenous immunoglobulin. Preparations for immunoglobulin G subclasses and specific antibodies to bacterial surface antigens and relation with their levels in treated immunodeficient patients.

Lamari F, Karamanos NK, Papadopoulou-Alataki E, Kanakoudi-Tsakalidou F, Dimitracopoulos G, Anastassiou ED.

J Pharm Biomed Anal. 2000 Jul;22(6):1029-36.

An enzyme immunoassay to determine the levels of specific antibodies toward bacterial surface antigens in human immunoglobulin preparations and blood serum.

Lamari F, Anastassiou ED, Tsegenidis T, Dimitracopoulos G, Karamanos NK.

J Pharm Biomed Anal. 1999 Sep;20(6):913-20.